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Sodium butyrate

(HB1399)
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Technical documents: SDS CoA Datasheet
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Product overview

Name Sodium butyrate
Alternative names NaB; SB
Description HDAC inhibitor. Directs mESC differentiation into hepatocytes.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (4) Frequently bought together
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Sodium butyrate product vial image | Hello Bio
Sodium butyrate product vial image | Hello Bio

Sodium butyrate product vial image | Hello Bio

Sodium butyrate product vial image | Hello Bio

Biological Data

Biological description Histone deacetylase (HDAC) inhibitor (IC50 values are 0.3, 0.3 and 0.4 mM for HDAC1, 7 and 2 respectively). Does not inhibit HDAC6 and HDAC10. Upregulates expression of pluripotency genes in iPSCs and directs mESC differentiation into hepatocytes. Improves cognition and shows anti-Alzheimer's disease and antidepressant actions.

Solubility & Handling

Solubility overview Soluble in water (100mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name Butanoic acid sodium salt
Molecular Weight 110.09
Chemical structure Sodium butyrate | [156-54-7] Chemical Structure
Molecular Formula C4H7NaO2
CAS Number 156-54-7
PubChem identifier 5222465
SMILES [Na+].CCCC([O-])=O
InChi InChI=1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
InChiKey MFBOGIVSZKQAPD-UHFFFAOYSA-M
MDL number MFCD00002816
Appearance White solid

References for Sodium butyrate

References are publications that support the biological activity of the product

  • Sodium butyrate functions as an antidepressant and improves cognition with enhanced neurotrophic expression in models of maternal deprivation and chronic mild stress.

    Valvassori SS et al (2014) Curr Neurovasc Res 11(4) : 359-66.
    Read more (PubMedID: 25233278)

  • Sodium butyrate efficiently converts fully reprogrammed induced pluripotent stem cells from mouse partially reprogrammed cells.

    Kang SJ et al (2014) Cell Reprogram 16(5) : 345-54.
    Read more (PubMedID: 25093667)

  • Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression.

    Govindarajan N et al (2011) J Alzheimers Dis 26(1) : 187-97.
    Read more (PubMedID: 21593570)

  • Histone deacetylase is a target of valproic acid-mediated cellular differentiation.

    Gurvich N et al (2004) Cancer Res 64(3) : 1079-86.
    Read more (PubMedID: 14871841)

4 Item(s)

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Grouped product items
Order: HB1399
Pack PriceQty
50mg
$46
250mg
$78
1g
$127
HDAC inhibitor. Directs mESC differentiation into hepatocytes.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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