Histone deacetylase (HDAC)
Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.
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(S)-4-Carboxyphenylglycine (HB0049)
Description:Competitive, selective group 1 mGlu antagonist
Purity:>99%
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CAT335 (HB8146)
Description:K2P2.1 (TREK-1) modulator. Used with ML336 as part of the CATKLAMP chemogenetic strategy. Selectively and irreversibly activates TREK-1CG* but not wild-type K2P2.1 (TREK-1)
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Purity:>98%
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Ceftriaxone disodium salt (HB0176)
Description:β-lactam antibiotic. Increases EAAT2 activity.
Purity:>98%
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Celastrol (HB4605)
Description:Anti-oxidant, anti-inflammatory compound with many actions. Topoisomerase II inhibitor.
Purity:>98%
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Cesium Gluconate (Cs-Gluc) (HB4822)
Description:Potassium channel blocker. Component in cesium gluconate-based internal solutions used for patch clamp electrophysiology.
