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Captopril

(HB3636)
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Product overview

Name Captopril
Alternative names CAP
Purity >98%
Description ACE and LTA4 hydrolase inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Biological Data

Biological description

Angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.022µM) which also inhibits LTA4 hydrolase in a reversible and competitive manner.

Shows antihypertensive and vasodilatory effects

Orally active.

Recently studied as part of COVID-19 compound repurposing.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in water (100mM) and in DMSO (100mM)
Handling In aqueous solution, Captopril undergoes a free radical dimerisation to form captopril disulfide. To delay oxidation, use a lower pH, degas solution, minimize headspace, increase the concentration or incorporate a chelating agent or antioxidant.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >98%
Chemical name 1-[(2S)-3-Mercapto-2-methyl-1-oxopropyl]-L-proline
Molecular Weight 217.29
Chemical structure Captopril [62571-86-2] Chemical Structure
Molecular Formula C9H15NO3S
CAS Number 62571-86-2
PubChem identifier 44093
SMILES O=C([C@H](C)CS)N1[C@H](C(O)=O)CCC1
InChi InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
InChiKey FAKRSMQSSFJEIM-RQJHMYQMSA-N
MDL number MFCD00168073

References for Captopril

References are publications that support the biological activity of the product

  • A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

    Gordon et al (2020) Nature : doi: 10.1038/s41586-020-2286-9.
    Read more (PubMedID: 32353859)

  • Effects of early captopril treatment and its removal on plasma angiotensin converting enzyme (ACE) activity and arginine vasopressin in hypertensive rats (SHR) and normotensive rats (WKY)

    Zhang et al (1996) Clin Exp Hypertens 18(2) : 201-26
    Read more (PubMedID: 8869001)

  • Captopril. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and congestive heart failure

    Brogden et al (1988) Drugs. 36(5) : 540-600
    Read more (PubMedID: 3063499)

3 Item(s)

Related Products
Grouped product items
Order: HB3636
Pack PriceQty
1g
$33
5g
$65
ACE and LTA4 hydrolase inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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