Product overview

Name CAT335
Purity >98%
Description K2P2.1 (TREK-1) modulator. Selectively and irreversibly activates TREK-1CG* but not wild-type K2P2.1 (TREK-1)
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Biological Data

Biological description K2P2.1 (TREK-1) modulator. Recently used with ML 336 as part of the CATKLAMP chemogenetic strategy which uses the pair of compounds to rapidly and irreversiblly activate engineered TREK subfamily members to allow further probing of K2P function and act as a switch to silence neuronal firing. When used with ML336, selectively and covalently activates engineered versions of different K2P TREK subfamily members e.g. K2P2.1 (TREK-1), K2P10.1 (TREK-2), K2P4.1(TRAAK).

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name N-[(2,4-dichlorophenyl)methyl]-4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzamide
Molecular Weight 375.21
Chemical structure  Chemical Structure
Molecular Formula C18H12Cl2N2O3
SMILES Clc1ccc(CNC(=O)c2ccc(cc2)N2C(=O)C=CC2=O)c(Cl)c1
Source Synthetic
InChi InChI=1S/C18H12Cl2N2O3/c19-13-4-1-12(15(20)9-13)10-21-18(25)11-2-5-14(6-3-11)22-16(23)7-8-17(22)24/h1-9H,10H2,(H,21,25)

References for CAT335

References are publications that support the biological activity of the product
  • Development of covalent chemogenetic K(2P) channel activators.

    Deal PE et al (2023) bioRxiv : the preprint server for biology :

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