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Images Ceftriaxone disodium salt product vial image | Hello Bio
Ceftriaxone disodium salt product vial image | Hello Bio Biological Data Biological description β-lactam antibiotic. Increases EAAT2 expression and EAAT2 biochemical and functional activity. Potentially reduces glutamergic toxicity. Shows neuroprotective actions in neurodegenerative disease models and antinociceptive effects in neuropathic pain.
Solubility & Handling Storage instructions +4°C
Solubility overview Soluble in DMSO (50 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt
Molecular Formula C18 H16 N8 Na2 O7 S3
PubChem identifier 9570985
SMILES CN1C(=NC(=O)C(=N1)[O-])SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)[O-].[Na+].[Na+]
InChiKey YOBPSXOHCHDCMU-VKZZUTNHSA-L
Appearance White to off-white
References for Ceftriaxone disodium salt References are publications that support the biological activity of the product
Ceftriaxone, a beta-lactam antibiotic, modulates apoptosis pathways and oxidative stress in a rat model of neuropathic pain. Amin B et al (2014) Biomed Res Int 2014 : 937568 Ceftriaxone mediated rescue of nigral oxidative damage and motor deficits in MPTP model of Parkinson's disease in rats. Bisht R et al (2014) Neurotoxicology 44 : 71-9. Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes. Lee SG et al (2008) J Biol Chem 283(19) : 13116-23.
β-lactam antibiotic. Increases EAAT2 activity.
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