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Capsazepine product vial image | Hello Bio

Biological Data

Biological description TRPV1 channel antagonist (IC50 = 562 nM). Converts N+, K+-ATPase into Na+-ATPase. Synthetic analog of capsaicin and competitive capsaicin antagonist. Displays analgesic and anticonvulsant properties.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in ethanol (25mM) and in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >97%
Chemical name N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide
Molecular Weight 376.9
Chemical structure Capsazepine  [138977-28-3] Chemical Structure
Molecular Formula C19H21ClN2O2S
CAS Number 138977-28-3
PubChem identifier 2733484
InChi InChI=1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
MDL number MFCD00153778

References for Capsazepine

References are publications that support the biological activity of the product
  • TRPV1 antagonist capsazepine suppresses 4-AP-induced epileptiform activity in vitro and electrographic seizures in vivo.

    Gonzalez-Reyes LE et al (2013) Exp Neurol 250 : 321-32.
  • Capsazepine, a synthetic vanilloid that converts the Na,K-ATPase to Na-ATPase.

    Mahmmoud YA (2008) Proc Natl Acad Sci U S A 105(5) : 1757-61.
  • Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin.

    Seabrook GR et al (2002) J Pharmacol Exp Ther 303(3) : 1052-60.
  • The discovery of capsazepine, the first competitive antagonist of the sensory neuron excitants capsaicin and resiniferatoxin.

    Walpole CS et al (1994) J Med Chem 37(13) : 1942-54.

4 Item(s)

These publications cite the use of Capsazepine purchased from Hello Bio:
  • Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome

    Pinto B et al (2020) Neuron 108(5) : 887-904.e12
    PubMedID: 33027640

1 Item