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(E)-Capsaicin

(HB1179)
Publications (3)

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Product overview

Name (E)-Capsaicin
Purity >95%
Customer comments

Fast service with an important tool that works perfect. Capsaicin is an agonist of TRPV1 receptors. Capsaicin offered by Hello Bio has an amazing price not offered by other suppliers. I definitely recommend it. Verified customer, University of Vigo

Description TRPV1 channel agonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (2) Publications (3) References (4) Frequently bought together
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Biological Data

Biological description TRPV1 channel agonist (pEC50 values are 7.10 and 7.97 for human and rat TRPV1 respectively). Carbonic anhydrase inhibitor (Ki values are 696.15 and 208.37 µM for hCAI an hCAII respectively). Also CYP3A subfamily and P-gp inhibitor. Induces cell cycle arrest, apoptosis and inhibits proliferation Displays apoptosis inducing,

Solubility & Handling

Solubility overview Soluble in DMSO (50mM) and in ethanol (50mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name (E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
Molecular Weight 305.42
Chemical structure (E)-Capsaicin [404-86-4] Chemical Structure
Molecular Formula C18H27NO3
CAS Number 404-86-4
PubChem identifier 1548943
SMILES CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC
InChi InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
InChiKey YKPUWZUDDOIDPM-SOFGYWHQSA-N
MDL number MFCD00017259

References for (E)-Capsaicin

References are publications that support the biological activity of the product

  • Capsaicin: a potent inhibitor of carbonic anhydrase isoenzymes.

    Arabaci B et al (2014) Molecules 19(7) : 10103-14.
    Read more (PubMedID: 25014536)

  • Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis.

    Bode AM et al (2009) Cancer Res 69(3) : 905-13.
    Read more (PubMedID: 19155296)

  • Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.

    Holzer P (1991) Pharmacol Rev 43(2) : 143-201.
    Read more (PubMedID: 1852779)

  • Sensory neuron-specific actions of capsaicin: mechanisms and applications.

    Bevan S et al (1990) Trends Pharmacol Sci 11(8) : 330-3.
    Read more (PubMedID: 2203194)

4 Item(s)

Publications
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These publications cite the use of (E)-Capsaicin purchased from Hello Bio:

  • Gating of the capsaicin receptor TRPV1 by UVA-light and oxidants are mediated by distinct mechanisms

    Pantke S et al (2021) Cell Calcium 96 : 102391
    PubMedID: 33752082

  • Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC) -derived sensory neurons

    Schinke C et al (2021) Neurobiol Dis 155 : 105391
    PubMedID: 33984509

  • Distinct Mechanisms Account for In Vitro Activation and Sensitization of TRPV1 by the Porphyrin Hemin

    Palmaers NE et al (2021) Int J Mol Sci 22(19)
    PubMedID: 34639197

3 Item(s)

Grouped product items
Order: HB1179
Pack PriceQty
50mg
$78
250mg
$303
TRPV1 channel agonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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