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Biological Data

Biological description CDPPB is a selective mGlu5 receptor positive allosteric modulator (EC50 = 27 nM for human mGlu5 receptor). It shows anti-psychotic and cognitive enhancing actions. CDPPB is blood-brain barrier permeable.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (75mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
Molecular Weight 364.4
Chemical structure CDPPB  [781652-57-1] Chemical Structure
Molecular Formula C23H16N4O
CAS Number 781652-57-1
PubChem identifier 11245456
SMILES C1=CC=C(C=C1)C2=NN(C(=C2)NC(=O)C3=CC=CC(=C3)C#N)C4=CC=CC=C4
Source Synthetic
InChi InChI=1S/C23H16N4O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20/h1-15H,(H,25,28)
InChiKey BKUIZWILNWHFHD-UHFFFAOYSA-N
Appearance White solid

References for CDPPB

References are publications that support the biological activity of the product
  • Effects of a metabotropic glutamate receptor 5 positive allosteric modulator, CDPPB, on spatial learning task performance in rodents.

    Fowler SW et al (2013) Neurobiol Learn Mem 99 : 25-31.
  • Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration.

    Parmentier-Batteur S et al (2012) Neuropharmacology 62(3) : 1453-60.
  • A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.

    Kinney GG et al (2005) J Pharmacol Exp Ther 313(1) : 199-206.