Product overview
| Name | CDPPB |
| Description | Selective mGlu5 positive allosteric modulator |
| Purity | >98% |
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Biological Data
| Biological description | CDPPB is a selective mGlu5 receptor positive allosteric modulator (EC50 = 27 nM for human mGlu5 receptor). It shows anti-psychotic and cognitive enhancing actions. CDPPB is blood-brain barrier permeable. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (75mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide |
| Molecular Weight | 364.4 |
| Chemical structure | ![CDPPB [781652-57-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0175.png "CDPPB [781652-57-1]") |
| Molecular Formula | C23H16N4O |
| CAS Number | 781652-57-1 |
| PubChem identifier | 11245456 |
| SMILES | C1=CC=C(C=C1)C2=NN(C(=C2)NC(=O)C3=CC=CC(=C3)C#N)C4=CC=CC=C4 |
| Source | Synthetic |
| InChi | InChI=1S/C23H16N4O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20/h1-15H,(H,25,28) |
| InChiKey | BKUIZWILNWHFHD-UHFFFAOYSA-N |
| Appearance | White solid |
References for CDPPB
References are publications that support the biological activity of the product
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Effects of a metabotropic glutamate receptor 5 positive allosteric modulator, CDPPB, on spatial learning task performance in rodents.
Fowler SW et al (2013) Neurobiol Learn Mem 99 : 25-31. -
Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration.
Parmentier-Batteur S et al (2012) Neuropharmacology 62(3) : 1453-60. -
A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.
Kinney GG et al (2005) J Pharmacol Exp Ther 313(1) : 199-206.
Technical guides
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