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CDPPB

(HB0175)
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Product overview

Name CDPPB
Purity >98%
Description Selective mGlu5 positive allosteric modulator
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (3) Reviews References (3) Frequently bought together
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Images

CDPPB product vial image | Hello Bio
CDPPB product vial image | Hello Bio

CDPPB product vial image | Hello Bio

CDPPB product vial image | Hello Bio

Biological Data

Biological description CDPPB is a selective mGlu5 receptor positive allosteric modulator (EC50 = 27 nM for human mGlu5 receptor). It shows anti-psychotic and cognitive enhancing actions. CDPPB is blood-brain barrier permeable.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (75mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >98%
Chemical name 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
Molecular Weight 364.4
Chemical structure CDPPB [781652-57-1] Chemical Structure
Molecular Formula C23H16N4O
CAS Number 781652-57-1
PubChem identifier 11245456
SMILES C1=CC=C(C=C1)C2=NN(C(=C2)NC(=O)C3=CC=CC(=C3)C#N)C4=CC=CC=C4
Source Synthetic
InChi InChI=1S/C23H16N4O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20/h1-15H,(H,25,28)
InChiKey BKUIZWILNWHFHD-UHFFFAOYSA-N
Appearance White solid

References for CDPPB

References are publications that support the biological activity of the product

  • Effects of a metabotropic glutamate receptor 5 positive allosteric modulator, CDPPB, on spatial learning task performance in rodents.

    Fowler SW et al (2013) Neurobiol Learn Mem 99 : 25-31.
    Read more (PubMedID: 23137441)

  • Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration.

    Parmentier-Batteur S et al (2012) Neuropharmacology 62(3) : 1453-60.
    Read more (PubMedID: 21112344)

  • A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.

    Kinney GG et al (2005) J Pharmacol Exp Ther 313(1) : 199-206.
    Read more (PubMedID: 15608073)

3 Item(s)

Related Products
Grouped product items
Order: HB0175
Pack PriceQty
10mg
$131
50mg
$519
Selective mGlu5 positive allosteric modulator
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Hazardous: $35

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