Target

Selective, non-competitive AMPA / kainate receptor antagonist

GluK6-PSD-95 interaction inhibitor

TRPM2 antagonist. Cell permeable.

Abundant free amino acid found in the brain.

Potent, selective Na_v1.7 inhibitor

Potent, non-competitive GluN2A subunit selective NMDA receptor antagonist

K_ir2.3 channel agonist

Potent inward rectifier K⁺ channel blocker

Potent, selective K_ir1.1 channel blocker

Non-selective K⁺ channel blocker