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Biological Data

Biological description Kir2.3 channel agonist (EC50 = 402 nM). Exhibits little or no activity at hKir2.1 and Kv1.5 channels. Also inhibits COX-1 and COX-2 (IC50 values are <0.03 and 1.2 µM respectively). Displays anti-inflammatory and neuroprotective properties.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



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Chemical Data

Purity >98%
Chemical name 5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide
Molecular Weight 320.75
Chemical structure Tenidap  [120210-48-2] Chemical Structure
Molecular Formula C14H9N2O3SCl
CAS Number 120210-48-2
PubChem identifier 54683953
InChi InChI=1S/C14H9ClN2O3S/c15-7-3-4-9-8(6-7)11(13(19)17(9)14(16)20)12(18)10-2-1-5-21-10/h1-6,19H,(H2,16,20)

References for Tenidap

References are publications that support the biological activity of the product
  • Tenidap, an agonist of the inwardly rectifying K+ channel Kir2.3, delays the onset of cortical epileptiform activity in a model of chronic temporal lobe epilepsy.

    Xu L et al (2013) Neurol Res 35(6) : 561-7.
  • Tenidap is neuroprotective in a pilocarpine rat model of temporal lobe epilepsy.

    Tang XH et al (2013) Chin Med J (Engl) 126(10) : 1900-5.
  • Tenidap, a novel anti-inflammatory agent, is an opener of the inwardly rectifying K+ channel hKir2.3.

    Liu Y et al (2002) Eur J Pharmacol 435(2-3) : 153-60.
  • Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation.

    Kirchner T et al (1997) J Pharmacol Exp Ther 282(2) : 1094-101.

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