Kir2.3 channel agonist (EC50 = 402 nM). Exhibits little or no activity at hKir2.1 and Kv1.5 channels. Also inhibits COX-1 and COX-2 (IC50 values are <0.03 and 1.2 µM respectively). Displays anti-inflammatory and neuroprotective properties.
Solubility & Handling
Storage instructions
+4°C
Solubility overview
Soluble in DMSO (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
References are publications that support the biological activity of the product
Tenidap, an agonist of the inwardly rectifying K+ channel Kir2.3, delays the onset of cortical epileptiform activity in a model of chronic temporal lobe epilepsy.
Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation.
Kirchner T et al (1997) J Pharmacol Exp Ther 282(2) : 1094-101.
![Tenidap [120210-48-2] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1097.png "Tenidap [120210-48-2]")
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