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Images Tertiapin-Q product vial image | Hello Bio
Tertiapin-Q product vial image | Hello Bio Biological Data Biological description Potent inward rectifier K+ channel blocker. Inhibits Kir 1.1 (ROMK1) and Kir 3.1/3.4 (GIRK1/4) (Kd values are 1.3 and 13.3 nM respectively).
Solubility & Handling Solubility overview Soluble in water (2mg/ml)
Storage instructions -20°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name ALC*NC*NRIIIPHQC*WKKC*GKK
(Modifications: Disulfide bonds 3 - 14 and 5 - 18, C-terminal amide)
Chemical structure
Molecular Formula C106 H175 N35 O24 S4
PubChem identifier 92131436
SMILES CC[C@H](C)[C@H]1C(=O)NC(C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]3CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC3=O)CC4=CNC5=CC=CC=C54)CCCCN)CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N)C(=O)N[C@H](C(=O)N1)CC(=O)N)CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)N)CCC(=O)N)CC6=CNC=N6)[C@@H](C)CC)[C@@H](C)CC
InChi InChI=1S/C100H163N31O23S4/c1-10-52(6)79-98(152)129-80(53(7)11-2)99(153)130-81(54(8)12-3)100(154)131-37-23-30-74(131)97(151)123-67(40-57-44-110-50-113-57)91(145)118-64(31-32-75(106)132)88(142)125-71-47-157-158-48-72(126-89(143)65(38-51(4)5)119-83(137)55(9)
InChiKey GYOKDEHVCCTTJF-VJPNZKQTSA-N
References for Tertiapin-Q References are publications that support the biological activity of the product
Engineered specific and high-affinity inhibitor for a subtype of inward-rectifier K+ channels. Ramu Y et al (2008) Proc Natl Acad Sci U S A 105(31) : 10774-8. The effects of tertiapin-Q on responses of the sinoatrial pacemaker of the guinea-pig heart to vagal nerve stimulation and muscarinic agonists. Bolter CP et al (2008) Exp Physiol 93(1) : 53-63. GABAergic activation of an inwardly rectifying K+ current in mouse cerebellar Purkinje cells. Tabata T et al (2005) J Physiol 563(Pt 2) : 443-57. Synthesis of a stable form of tertiapin: a high-affinity inhibitor for inward-rectifier K+ channels. Jin W et al (1999) Biochemistry 38(43) : 14286-93.
Publications
These publications cite the use of Tertiapin-Q purchased from Hello Bio:
An Etiological Foxp2 Mutation Impairs Neuronal Gain in Layer VI Cortico-Thalamic Cells through Increased GABAB /GIRK Signaling Druart M et al (2020) J Neurosci 40(44) : 8543-8555
Potent inward rectifier K+ channel blocker
![Tertiapin-Q [910044-56-3] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1108_1.png "Tertiapin-Q [910044-56-3]")
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