Product overview

Name Tertiapin-Q
Purity >95%
Description Potent inward rectifier K+ channel blocker
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Biological Data

Biological description Potent inward rectifier K+ channel blocker. Inhibits Kir1.1 (ROMK1) and Kir3.1/3.4 (GIRK1/4) (Kd values are 1.3 and 13.3 nM respectively).

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (2mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >95%
Chemical name ALC*NC*NRIIIPHQC*WKKC*GKK (Modifications: Disulfide bonds 3 - 14 and 5 - 18, C-terminal amide)
Molecular Weight 2453.06
Chemical structure Tertiapin-Q  [910044-56-3] Chemical Structure
Molecular Formula C106H175N35O24S4
CAS Number 910044-56-3
PubChem identifier 92131436
SMILES CC[C@H](C)[C@H]1C(=O)NC(C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]3CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC3=O)CC4=CNC5=CC=CC=C54)CCCCN)CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N)C(=O)N[C@H](C(=O)N1)CC(=O)N)CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)N)CCC(=O)N)CC6=CNC=N6)[C@@H](C)CC)[C@@H](C)CC
InChi InChI=1S/C100H163N31O23S4/c1-10-52(6)79-98(152)129-80(53(7)11-2)99(153)130-81(54(8)12-3)100(154)131-37-23-30-74(131)97(151)123-67(40-57-44-110-50-113-57)91(145)118-64(31-32-75(106)132)88(142)125-71-47-157-158-48-72(126-89(143)65(38-51(4)5)119-83(137)55(9)
MDL number MFCD02684419

References for Tertiapin-Q

References are publications that support the biological activity of the product
  • Engineered specific and high-affinity inhibitor for a subtype of inward-rectifier K+ channels.

    Ramu Y et al (2008) Proc Natl Acad Sci U S A 105(31) : 10774-8.
  • The effects of tertiapin-Q on responses of the sinoatrial pacemaker of the guinea-pig heart to vagal nerve stimulation and muscarinic agonists.

    Bolter CP et al (2008) Exp Physiol 93(1) : 53-63.
  • GABAergic activation of an inwardly rectifying K+ current in mouse cerebellar Purkinje cells.

    Tabata T et al (2005) J Physiol 563(Pt 2) : 443-57.
  • Synthesis of a stable form of tertiapin: a high-affinity inhibitor for inward-rectifier K+ channels.

    Jin W et al (1999) Biochemistry 38(43) : 14286-93.

4 Item(s)

These publications cite the use of Tertiapin-Q purchased from Hello Bio:
  • An Etiological Foxp2 Mutation Impairs Neuronal Gain in Layer VI Cortico-Thalamic Cells through Increased GABAB/GIRK Signaling

    Druart M et al (2020) J Neurosci 40(44) : 8543-8555
    PubMedID: 33020214

1 Item