Product overview

Name TCN 201
Description Potent, non-competitive GluN2A subunit selective NMDA receptor antagonist
Purity >99%
Write Your Own Review
You're reviewing:TCN 201
Rate this item:

Images

TCN 201: Scientist Approved

Biological Data

Biological description Potent and non-competitive GluN2A subunit selective NMDA receptor antagonist (pIC50 values are 6.8 and <4.3 for GluN2A and GluN2B respectively in a FLIPR/Ca2+ assay). Binds at allosteric site. Inhibition is GluN1 co-agonist (glycine or D-serine) concentration dependent. Shows anti-nicotine addiction effects.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Chemical name 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide
Molecular Weight 461.89
Chemical structure Chemical structure
Molecular Formula C21H17ClFN3O4S
CAS Number 852918-02-6
PubChem identifier 4787937
SMILES C1=CC=C(C=C1)C(=O)NNC(=O)C2=CC=C(C=C2)CNS(=O)(=O)C3=CC(=C(C=C3)F)Cl
InChi InChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
InChiKey FYIBXBFDXNPBSF-UHFFFAOYSA-N
MDL number MFCD06683895
Appearance White solid

References for TCN 201

References are publications that support the biological activity of the product
  • Reinstatement of nicotine seeking is mediated by glutamatergic plasticity.

    Gipson CD et al (2013) Proc Natl Acad Sci U S A 110(22) : 9124-9.
  • Subunit-selective allosteric inhibition of glycine binding to NMDA receptors.

    Hansen KB et al (2012) J Neurosci 32(18) : 6197-208.
  • TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner.

    Edman S et al (2012) Neuropharmacology 63(3) : 441-9.
  • Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.

    Bettini E et al (2010) J Pharmacol Exp Ther 335(3) : 636-44.
Publications
These publications cite the use of TCN 201 purchased from Hello Bio:
  • The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators.

    Sapkota et al (2019) Biochem Pharmacol 159 : 140-153
    PubMedID: 30503374
  • Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.

    Yi et al (2016) Neuron 91(6) : 1316-29
    PubMedID: 27618671

2 Item(s)