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TCN 201

(HB0604)
Publications (3)

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Product overview

Name TCN 201
Purity >99%
Description Potent, non-competitive GluN2A subunit selective NMDA receptor antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (4) Reviews Publications (3) References (4) Frequently bought together
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TCN 201: Scientist Approved
TCN 201: Scientist Approved
TCN 201 product vial image | Hello Bio
TCN 201 product vial image | Hello Bio

TCN 201: Scientist Approved

TCN 201: Scientist Approved

TCN 201 product vial image | Hello Bio

TCN 201 product vial image | Hello Bio

Biological Data

Biological description Potent and non-competitive GluN2A subunit selective NMDA receptor antagonist (pIC50 values are 6.8 and <4.3 for GluN2A and GluN2B respectively in a FLIPR/Ca2+ assay). Binds at allosteric site. Inhibition is GluN1 co-agonist (glycine or D-serine) concentration dependent. Shows anti-nicotine addiction effects.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide
Molecular Weight 461.89
Chemical structure TCN 201 [852918-02-6] Chemical Structure
Molecular Formula C21H17ClFN3O4S
CAS Number 852918-02-6
PubChem identifier 4787937
SMILES C1=CC=C(C=C1)C(=O)NNC(=O)C2=CC=C(C=C2)CNS(=O)(=O)C3=CC(=C(C=C3)F)Cl
InChi InChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
InChiKey FYIBXBFDXNPBSF-UHFFFAOYSA-N
MDL number MFCD06683895
Appearance White solid

References for TCN 201

References are publications that support the biological activity of the product

  • Reinstatement of nicotine seeking is mediated by glutamatergic plasticity.

    Gipson CD et al (2013) Proc Natl Acad Sci U S A 110(22) : 9124-9.
    Read more (PubMedID: 23671067)

  • Subunit-selective allosteric inhibition of glycine binding to NMDA receptors.

    Hansen KB et al (2012) J Neurosci 32(18) : 6197-208.
    Read more (PubMedID: 22553026)

  • TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner.

    Edman S et al (2012) Neuropharmacology 63(3) : 441-9.
    Read more (PubMedID: 22579927)

  • Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.

    Bettini E et al (2010) J Pharmacol Exp Ther 335(3) : 636-44.
    Read more (PubMedID: 20810618)

4 Item(s)

Publications
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These publications cite the use of TCN 201 purchased from Hello Bio:

  • The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators.

    Sapkota et al (2019) Biochem Pharmacol 159 : 140-153
    PubMedID: 30503374

  • Ligand binding domain interface: A tipping point for pharmacological agents binding with GluN1/2A subunit containing NMDA receptors

    Bledsoe D et al (2019) Eur J Pharmacol 844 : 216-224
    PubMedID: 30553788

  • Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.

    Yi et al (2016) Neuron 91(6) : 1316-29
    PubMedID: 27618671

3 Item(s)

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Order: HB0604
Pack PriceQty
10mg
$176
50mg
$734
Potent, non-competitive GluN2A subunit selective NMDA receptor antagonist
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Hazardous: $35

Shipped on ice: $35

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