Product overview

Name TCN 201
Description Potent, non-competitive GluN2A subunit selective NMDA receptor antagonist
Purity >99%
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TCN 201: Scientist Approved

Biological Data

Biological description Potent and non-competitive GluN2A subunit selective NMDA receptor antagonist (pIC50 values are 6.8 and <4.3 for GluN2A and GluN2B respectively in a FLIPR/Ca2+ assay). Binds at allosteric site. Inhibition is GluN1 co-agonist (glycine or D-serine) concentration dependent. Shows anti-nicotine addiction effects.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Chemical name 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide
Molecular Weight 461.89
Chemical structure Chemical structure
Molecular Formula C21H17ClFN3O4S
CAS Number 852918-02-6
PubChem identifier 4787937
SMILES C1=CC=C(C=C1)C(=O)NNC(=O)C2=CC=C(C=C2)CNS(=O)(=O)C3=CC(=C(C=C3)F)Cl
InChi InChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
MDL number MFCD06683895
Appearance White solid

References for TCN 201

References are publications that support the biological activity of the product
  • Reinstatement of nicotine seeking is mediated by glutamatergic plasticity.

    Gipson CD et al (2013) Proc Natl Acad Sci U S A 110(22) : 9124-9.
  • Subunit-selective allosteric inhibition of glycine binding to NMDA receptors.

    Hansen KB et al (2012) J Neurosci 32(18) : 6197-208.
  • TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner.

    Edman S et al (2012) Neuropharmacology 63(3) : 441-9.
  • Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.

    Bettini E et al (2010) J Pharmacol Exp Ther 335(3) : 636-44.
These publications cite the use of TCN 201 purchased from Hello Bio:
  • The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators.

    Sapkota et al (2019) Biochem Pharmacol 159 : 140-153
    PubMedID: 30503374
  • Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.

    Yi et al (2016) Neuron 91(6) : 1316-29
    PubMedID: 27618671

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