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Biological Data
| Biological description | Selective and non-competitive AMPA/ kainate receptor antagonist. Binds to allosteric site. Potentiates anticonvulsive activity of antiepileptic drugs. Displays anticonvulsant activity. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Chemical name | (8R)-7-Acetyl-5-(4-aminophenyl)-8,9 -dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine |
| Chemical structure | ![Talampanel [161832-65-1] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Talampanel [161832-65-1]") |
| Molecular Formula | C19H19N3O3 |
| PubChem identifier | 164509 |
| SMILES | NC(C=C4)=CC=C4C1=NN(C(C)=O)[C@H](C)CC2=C1C=C(OCO3)C3=C2 |
| InChi | InChI=1S/C19H19N3O3/c1-11-7-14-8-17-18(25-10-24-17)9-16(14)19(21-22(11)12(2)23)13-3-5-15(20)6-4-13/h3-6,8-9,11H,7,10,20H2,1-2H3/t11-/m1/s1 |
| InChiKey | JACAAXNEHGBPOQ-LLVKDONJSA-N |
References for Talampanel
References are publications that support the biological activity of the product
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Talampanel suppresses the acute and chronic effects of seizures in a rodent neonatal seizure model.
Aujla PK et al (2009) Epilepsia 50(4) : 694-701. -
Talampanel, a novel noncompetitive AMPA antagonist, is neuroprotective after traumatic brain injury in rats.
Belayev L et al (2001) J Neurotrauma 18(10) : 1031-8. -
LY 300164, a novel antagonist of AMPA/kainate receptors, potentiates the anticonvulsive activity of antiepileptic drugs.
Czuczwar SJ et al (1998) Eur J Pharmacol 359(2-3) : 103-9.
Selective, non-competitive AMPA / kainate receptor antagonist
![Talampanel [161832-65-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0600.png "Talampanel [161832-65-1]")
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