Target

Non-competitive AMPA receptor antagonist. Also blocks kainate GluK3 homomeric receptors.

Selective TRPA1 channel blocker

Potent, selective TRPV4 channel antagonist

Potent, selective TRPV4 channel antagonist. Hydrochloride salt

Selective TRPC6 channel activator and neurotransmitter re-uptake inhibitor

Non-selective endogenous glycine receptor agonist 

Potent, reversible, selective K_Ca channel inhibitor

Non-selective NMDA / mGlu receptor agonist

K_v7.4 channel activator

Potent, selective Na_v1.3 / Na_v1.1 channel inhibitor