Product overview
| Name | Ibotenic acid |
| Description | Non-selective NMDA / mGlu receptor agonist |
| Purity | >98% |
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Biological Data
| Biological description | Non-selective NMDA and mGlu receptor agonist (EC50 values are 17, 43, 110, >1000 and >1000 μM for mGlu5a, mGlu1a, mGlu2, mGlu4a and mGlu6 receptors respectively). Shows excitotoxic actions. Used for cognitive dysfunction models for neurodegenerative disease research. |
Solubility & Handling
| Storage instructions | -20°C (desiccate) |
| Solubility overview | Soluble in water (10mM) and in 0.1M NaOH (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Purity | >98% |
| Chemical name | α-Amino-(3-hydroxy-5-isoxazolyl)acetic acid |
| Molecular Weight | 158.11 |
| Chemical structure | ![Ibotenic acid [2552-55-8] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0330.png "Ibotenic acid [2552-55-8]") |
| Molecular Formula | C5H6N2O4 |
| CAS Number | 2552-55-8 |
| PubChem identifier | 1233 |
| SMILES | C1=C(ONC1=O)C(C(=O)O)N |
| Source | Synthetic |
| InChi | InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10) |
| InChiKey | IRJCBFDCFXCWGO-UHFFFAOYSA-N |
| MDL number | MFCD00069294 |
| Appearance | White solid |
References for Ibotenic acid
References are publications that support the biological activity of the product
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Neurochemical and behavioral effects of the intrahippocampal co-injection of beta-amyloid protein1-40 and ibotenic acid in rats.
Li Y et al (2005) Life Sci 76(11) : 1189-97. -
Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors.
Hermit MB et al (2004) Eur J Pharmacol 486(3) : 241-50. -
Molecular pharmacology of homologues of ibotenic acid at cloned metabotropic glutamic acid receptors.
Bräuner-Osborne H et al (1998) Eur J Pharmacol 350(2-3) : 311-6. -
Isomers of 2-amino-7-phosphonoheptanoic acid as antagonists of neuronal excitants.
Perkins MN et al (1982) Neurosci Lett 32(1) : 65-8.
Publications
These publications cite the use of Ibotenic acid purchased from Hello Bio:
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Further development of a liquid chromatography-high-resolution mass spectrometry/mass spectrometry-based strategy for analyzing eight biomarkers in human urine indicating toxic mushroom or Ricinus communis ingestions
Bambauer TP et al (2021) Drug Test Anal 13(9) : 1603-1613PubMedID: 34080326 -
Development and application of a strategy for analyzing eight biomarkers in human urine to verify toxic mushroom or ricinus communis ingestions by means of hydrophilic interaction LC coupled to HRMS/MS
Bambauer et al. (2020) Talanta 213 (120847) : 1-8PubMedID: 32200933 -
Evaluation of novel organosilane modifications of paper spray mass spectrometry substrates for analyzing polar compounds
Bambauer TP et al (2019) Talanta : 677-684PubMedID: 31357352
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