Product overview

Name Ibotenic acid
Description Non-selective NMDA / mGlu receptor agonist
Purity >98%
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Ibotenic acid product vial image | Hello Bio

Biological Data

Biological description Non-selective NMDA and mGlu receptor agonist (EC50 values are 17, 43, 110, >1000 and >1000 μM for mGlu5a, mGlu1a, mGlu2, mGlu4a and mGlu6 receptors respectively). Shows excitotoxic actions. Used for cognitive dysfunction models for neurodegenerative disease research.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (10mM) and in 0.1M NaOH (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name α-Amino-(3-hydroxy-5-isoxazolyl)acetic acid
Molecular Weight 158.11
Chemical structure Ibotenic acid  [2552-55-8] Chemical Structure
Molecular Formula C5H6N2O4
CAS Number 2552-55-8
PubChem identifier 1233
Source Synthetic
InChi InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
MDL number MFCD00069294
Appearance White solid

References for Ibotenic acid

References are publications that support the biological activity of the product
  • Neurochemical and behavioral effects of the intrahippocampal co-injection of beta-amyloid protein1-40 and ibotenic acid in rats.

    Li Y et al (2005) Life Sci 76(11) : 1189-97.
  • Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors.

    Hermit MB et al (2004) Eur J Pharmacol 486(3) : 241-50.
  • Molecular pharmacology of homologues of ibotenic acid at cloned metabotropic glutamic acid receptors.

    Bräuner-Osborne H et al (1998) Eur J Pharmacol 350(2-3) : 311-6.
  • Isomers of 2-amino-7-phosphonoheptanoic acid as antagonists of neuronal excitants.

    Perkins MN et al (1982) Neurosci Lett 32(1) : 65-8.

4 Item(s)

These publications cite the use of Ibotenic acid purchased from Hello Bio:
  • Further development of a liquid chromatography-high-resolution mass spectrometry/mass spectrometry-based strategy for analyzing eight biomarkers in human urine indicating toxic mushroom or Ricinus communis ingestions

    Bambauer TP et al (2021) Drug Test Anal 13(9) : 1603-1613
    PubMedID: 34080326
  • Development and application of a strategy for analyzing eight biomarkers in human urine to verify toxic mushroom or ricinus communis ingestions by means of hydrophilic interaction LC coupled to HRMS/MS

    Bambauer et al. (2020) Talanta 213 (120847) : 1-8
    PubMedID: 32200933
  • Evaluation of novel organosilane modifications of paper spray mass spectrometry substrates for analyzing polar compounds

    Bambauer TP et al (2019) Talanta : 677-684
    PubMedID: 31357352

3 Item(s)