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Images Iberiotoxin product vial image | Hello Bio
Iberiotoxin product vial image | Hello Bio Biological Data Biological description Potent, reversible and selective KCa channel inhibitor (approx IC50 = 250 pM). Found in venom of Buthus tamulus scorpion.
Solubility & Handling Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (0.7mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical structure
Molecular Formula C179 H276 N50 O56 S7
PubChem identifier 16132435
SMILES CC(C)CC1C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)O)CCCCN)NC(=O)C(C(C)C)NC(=O)C(CO)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C4CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N4)CCC(=O)O)CCCCN)CO)C(C)C)CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)C)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CC5=CC=CC=C5)NC(=O)C6CCC(=O)N6)C(=O)NC(CCSC)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC7CSSCC(NC(=O)C(NC7=O)CCCNC(=N)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)NC(CCC(=O)N)C(=O)O)CCCCN)CCCNC(=N)N)CC(=O)O)C(C)C)CC9=CC=CC=C9
Source Mesobuthus tamulus
InChi InChI=1S/C179H274N50O55S7/c1-87(2)65-111-155(261)208-112(66-93-33-15-13-16-34-93)146(252)195-77-133(239)225-139(88(3)4)172(278)213-117(71-136(244)245)158(264)199-100(44-31-62-190-178(186)187)144(250)193-75-131(237)198-102(40-22-27-58-181)148(254)219-124(1
InChiKey VDNVVLOBNHIMQA-UHFFFAOYSA-N
References for Iberiotoxin References are publications that support the biological activity of the product
A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin. Meera P et al (2000) Proc Natl Acad Sci U S A 97(10) : 5562-7. Mode of action of iberiotoxin, a potent blocker of the large conductance Ca(2+)-activated K+ channel. Candia S et al (1992) Biophys J 63(2) : 583-90. Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. Galvez A et al (1990) J Biol Chem 265(19) : 11083-90.
Potent, reversible, selective KCa channel inhibitor
![Iberiotoxin [129203-60-7] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1053_1.png "Iberiotoxin [129203-60-7]")
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