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Iberiotoxin

(HB1053)
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Product overview

Name Iberiotoxin
Purity >95%
Description Potent, reversible, selective KCa channel inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Images

Iberiotoxin product vial image | Hello Bio
Iberiotoxin product vial image | Hello Bio

Iberiotoxin product vial image | Hello Bio

Iberiotoxin product vial image | Hello Bio

Biological Data

Biological description Potent, reversible and selective KCa channel inhibitor (approx IC50 = 250 pM). Found in venom of Buthus tamulus scorpion.

Solubility & Handling

Solubility overview Soluble in water (0.7mg/ml)
Storage instructions -20°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Molecular Weight 4230.9
Chemical structure Iberiotoxin [129203-60-7] Chemical Structure
Molecular Formula C179H276N50O56S7
CAS Number 129203-60-7
PubChem identifier 16132435
SMILES CC(C)CC1C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)O)CCCCN)NC(=O)C(C(C)C)NC(=O)C(CO)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C4CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N4)CCC(=O)O)CCCCN)CO)C(C)C)CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)C)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CC5=CC=CC=C5)NC(=O)C6CCC(=O)N6)C(=O)NC(CCSC)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC7CSSCC(NC(=O)C(NC7=O)CCCNC(=N)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)NC(CCC(=O)N)C(=O)O)CCCCN)CCCNC(=N)N)CC(=O)O)C(C)C)CC9=CC=CC=C9
Source Mesobuthus tamulus
InChi InChI=1S/C179H274N50O55S7/c1-87(2)65-111-155(261)208-112(66-93-33-15-13-16-34-93)146(252)195-77-133(239)225-139(88(3)4)172(278)213-117(71-136(244)245)158(264)199-100(44-31-62-190-178(186)187)144(250)193-75-131(237)198-102(40-22-27-58-181)148(254)219-124(1
InChiKey VDNVVLOBNHIMQA-UHFFFAOYSA-N

References for Iberiotoxin

References are publications that support the biological activity of the product

  • A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin.

    Meera P et al (2000) Proc Natl Acad Sci U S A 97(10) : 5562-7.
    Read more (PubMedID: 10792058)

  • Mode of action of iberiotoxin, a potent blocker of the large conductance Ca(2+)-activated K+ channel.

    Candia S et al (1992) Biophys J 63(2) : 583-90.
    Read more (PubMedID: 1384740)

  • Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus.

    Galvez A et al (1990) J Biol Chem 265(19) : 11083-90.
    Read more (PubMedID: 1694175)

3 Item(s)

Grouped product items
Order: HB1053
Pack PriceQty
100μg
$253
Potent, reversible, selective KCa channel inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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