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ICA 069673

(HB1061)
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Product overview

Name ICA 069673
Purity >99%
Description Kv7.4 channel activator
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (2) Frequently bought together
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Biological Data

Biological description Kv7.4 channel activator. Also Kv7.2/7.3 and Kv7.3/7.5 channel activator (EC50 values are 0.69 and 14.3 µM respectively). Displays no or little activity at Kv11.1, Nav1.5, Kv7.1 and GABAA channels.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM) or ethanol (25mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
Molecular Weight 269.63
Chemical structure ICA 069673 [582323-16-8] Chemical Structure
Molecular Formula C11H6ClF2N3O
CAS Number 582323-16-8
PubChem identifier 10149311
SMILES ClC1=NC=C(NC(C2=CC(F)=C(F)C=C2)=O)C=N1
InChiKey IIBSHMFXVWTQSJ-UHFFFAOYSA-N

References for ICA 069673

References are publications that support the biological activity of the product

  • Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673.

    Brueggemann LI et al (2014) Mol Pharmacol 86(3) : 330-41.
    Read more (PubMedID: 24944189)

  • N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy.

    Amato G et al (2011) ACS Med Chem Lett 2(6) : 481-4.
    Read more (PubMedID: 24900334)

2 Item(s)

Grouped product items
Order: HB1061
Pack PriceQty
10mg
$176
50mg
$705
Kv7.4 channel activator
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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