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HC 030031

(HB1158)
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Product overview

Name HC 030031
Purity >99%
Description Selective TRPA1 channel blocker
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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HC 030031 product vial image | Hello Bio
HC 030031 product vial image | Hello Bio

HC 030031 product vial image | Hello Bio

HC 030031 product vial image | Hello Bio

Biological Data

Biological description Selective TRPA1 channel blocker (IC50 values are 0.7 and 1.2 µM for AITC- and formalin activated TRPA1 channels respectively). Displays little or no activity at TRPV1, TRPV3, TRPV4, hERG and Nav1.2 channels (IC50 values >10 µM). Also anatgonizes AITC- and formalin evoked Ca2+ influx (IC50 values are 6.2 and 5.3 µM respectively). Attenuates neuropathy- and inflammatory- induced mechanical hypersensitivity.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >99%
Chemical name 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acet amide
Molecular Weight 355.39
Chemical structure HC 030031 [349085-38-7] Chemical Structure
Molecular Formula C18H21N5O3
CAS Number 349085-38-7
PubChem identifier 1150897
SMILES O=C1C2=C(N=CN2CC(NC3=CC=C(C(C)C)C=C3)=O)N(C)C(N1C)=O
InChiKey HEQDZPHDVAOBLN-UHFFFAOYSA-N

References for HC 030031

References are publications that support the biological activity of the product

  • Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia.

    Ro JY et al (2009) Pain 144(3) : 270-7.
    Read more (PubMedID: 19464796)

  • HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity.

    Eid SR et al (2008) Mol Pain 4 : 48
    Read more (PubMedID: 18954467)

  • TRPA1 mediates formalin-induced pain.

    McNamara CR et al (2007) Proc Natl Acad Sci U S A 104(33) : 13525-30.
    Read more (PubMedID: 17686976)

3 Item(s)

Grouped product items
Order: HB1158
Pack PriceQty
10mg
$108
50mg
$406
Selective TRPA1 channel blocker
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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