Potent and selective TRPV4 channel antagonist (IC50 values are 17, 48 and 133 nM for mouse, human and rat TRPV4 channels respectively). Increases ATP release from porcine lenses (IC50 = 2.5 µM). Also reduces 4α-phorbol 12,13-didecanoate (4α-PDD)-induced Ca2+ responses (IC50 = 22 nM). Exhibits reduced activity for TRPM8 and hERG channels. Hydrochloride salt.
Solubility & Handling
Storage instructions
Room temperature
Solubility overview
Soluble in DMSO (100 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats.
Dahan D et al (2012) Am J Physiol Lung Cell Mol Physiol 303(9) : L824-33.
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