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HC 067047 hydrochloride

(HB6100)
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Technical documents: SDS CoA Datasheet

Product overview

Name HC 067047 hydrochloride
Purity >98%
Description Potent, selective TRPV4 channel antagonist. Hydrochloride salt
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Potent and selective TRPV4 channel antagonist (IC50 values are 17, 48 and 133 nM for mouse, human and rat TRPV4 channels respectively). Increases ATP release from porcine lenses (IC50 = 2.5 µM). Also reduces 4α-phorbol 12,13-didecanoate (4α-PDD)-induced Ca2+ responses (IC50 = 22 nM). Exhibits reduced activity for TRPM8 and hERG channels. Hydrochloride salt.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide hydrochloride
Molecular Weight 507.2
Chemical structure HC067047.HCl Chemical Structure
Molecular Formula C26H28F3N3O2.HCl
PubChem identifier 89894200
SMILES CC1=C(C=C(N1CCCN2CCOCC2)C3=CC=CC=C3)C(=O)NC4=CC=CC(=C4)C(F)(F)F.Cl
Source Synthetic
InChi InChI=1S/C26H28F3N3O2.ClH/c1-19-23(25(33)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31-13-15-34-16-14-31;/h2-5,7-10,17-18H,6,11-16H2,1H3,(H,30,33);1H
InChiKey OYEPECVNCLAKTO-UHFFFAOYSA-N

References for HC 067047 hydrochloride

References are publications that support the biological activity of the product

  • TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity.

    Shahidullah M et al (2012) Am J Physiol Cell Physiol 302(12) : C1751-61.
    Read more (PubMedID: 22492652)

  • Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats.

    Dahan D et al (2012) Am J Physiol Lung Cell Mol Physiol 303(9) : L824-33.
    Read more (PubMedID: 22962011)

  • Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.

    Everaerts W et al (2010) Proc Natl Acad Sci U S A 107(44) : 19084-9.
    Read more (PubMedID: 20956320)

3 Item(s)

Grouped product items
Order: HB6100
Pack PriceQty
5mg
$72
25mg
$278
Potent, selective TRPV4 channel antagonist. Hydrochloride salt
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Hazardous: $35

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