CHIR 99021 trihydrochloride
(HB1262)
Product overview
| Name | CHIR 99021 trihydrochloride |
| Description | Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons. Water soluble. |
| Purity | >98% |
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Biological Data
| Biological description | Potent, selective and ATP-competitive GSK3 β inhibitor (IC50 values are 6.7 and 10 nM for GSK-3β and GSK-3α respectively).
Commonly used in organoid production and also involved in reprogramming of fibroblasts to mature neurons. |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in water (25mM) and in DMSO (50mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethy l]amino]-3-pyridinecarbonitrile trihydrochloride |
| Molecular Weight | 574.72 |
| Chemical structure | ![CHIR 99021 trihydrochloride [1782235-14-6] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1262.png "CHIR 99021 trihydrochloride [1782235-14-6]") |
| Molecular Formula | C22H18Cl2N8.3HCl |
| CAS Number | 1782235-14-6 |
| PubChem identifier | 78243722 |
| SMILES | CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N.Cl.Cl.Cl |
| Source | Synthetic |
| InChi | InChI=1S/C22H18Cl2N8.3ClH/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19;;;/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32);3*1H |
| InChiKey | DSFVSCNMMZRCIA-UHFFFAOYSA-N |
| MDL number | MFCD11846251 |
References for CHIR 99021 trihydrochloride
References are publications that support the biological activity of the product
-
The roles of Notch3 on the cell proliferation and apoptosis induced by CHIR99021 in NSCLC cell lines: a functional link between Wnt and Notch signaling pathways.
Li C et al (2013) PLoS One 8(12) : e84659. -
Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains.
Ye S et al (2012) PLoS One 7(4) : e35892. -
Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2.
Li W et al (2009) Stem cells 27(12) : 2992-3000
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