Product overview
| Name | Forskolin |
| Description | Cell permeable, reversible adenylyl cyclase activator. Neuronal differentiation inducer. Used in production of liver organoids. |
| Purity | >98% |
| Customer comments | I am currently working with forskolin. The quality of product and service is very satisfying. I am very happy to have access to your high quality products. Pojeong Park, PhD student, University of Bristol, UK Very satisfied with this product, it works as expected in our liver tumouroid cultures. Hello Bio are a fantastic company that keep you informed of your order throughout the delivery process. Also a fan of the datasheets they provide. Verified customer, UK |
Images
Biological Data
| Biological description | Cell permeable, reversible adenylyl cyclase activator which increases cAMP levels and inhibits platelet-activating factor (PAF). It also inhibits mast cell degranulation and lowers intraocular pressure. It is used as a neuronal differentiation inducer. It is also used as a 3D Growth matrix component and used in production of liver organoids. Also displays vasodilating and hypotensive properties. |
| Application notes | Figures 1 - 3 show liver hepatocellular carcinoma tumouroids cultured with forskolin and A 83-01 |
Solubility & Handling
| Storage instructions | -20°C (desiccate) |
| Solubility overview | Soluble in DMSO (25 mM) |
| Handling | Cell culture media can be prewarmed before adding the compound to avoid potential precipitation of the compound. |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | [3R-(3<α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one |
| Molecular Weight | 410.51 |
| Chemical structure | ![Forskolin [66575-29-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1348.png "Forskolin [66575-29-9]") |
| Molecular Formula | C22H34O7 |
| CAS Number | 66575-29-9 |
| PubChem identifier | 47936 |
| SMILES | CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O |
| InChi | InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1 |
| InChiKey | OHCQJHSOBUTRHG-KGGHGJDLSA-N |
| MDL number | MFCD00082317 |
References for Forskolin
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Forskolin and derivatives as tools for studying the role of cAMP.
Alasbahi RH et al (2012) Pharmazie 67(1) : 5-13. -
Forskolin: upcoming antiglaucoma molecule.
Wagh VD et al (2012) J Postgrad Med 58(3) : 199-202. -
Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling.
Insel PA et al (2003) Cell Mol Neurobiol 23(3) : 305-14. -
Interactions of forskolin and adenylate cyclase. Effects on substrate kinetics and protection against inactivation by heat and N-ethylmaleimide.
Awad JA et al (1983) J Biol Chem 258(5) : 2960-5.
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TRV130 partial agonism and capacity to induce anti-nociceptive tolerance revealed through reducing available μ-opioid receptor number
Singleton S et al (2021) Br J Pharmacol 178(8) : 1855-1868PubMedID: 33555037 -
Differential regulation of prelimbic and thalamic transmission to the basolateral amygdala by acetylcholine receptors
Mott et al (2021) bioRxiv https://doi.org/10.1101/2021.12.28.474396 : doi -
The residence of synaptically released dopamine on D2 autoreceptors
Condon AF et al (2021) Cell Rep 36(5) : 109465PubMedID: 34348146 -
Chemical Stimulation of Rodent and Human Cortical Synaptosomes: Implications in Neurodegeneration
Ahmad et al (2021) Cells 10(5) : 1174 -
Activation of μ-opioid receptors by MT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine) and its fluorinated derivatives
Baptista-Hon DT et al (2020) Br J Pharmacol 177(15) : 3436-3448PubMedID: 32246840
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