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Technical documents: SDS CoA Datasheet

Product overview

Name Forskolin
Purity >98%
Customer comments

I am currently working with forskolin. The quality of product and service is very satisfying. I am very happy to have access to your high quality products. Pojeong Park, PhD student, University of Bristol, UK

Very satisfied with this product, it works as expected in our liver tumouroid cultures. Hello Bio are a fantastic company that keep you informed of your order throughout the delivery process. Also a fan of the datasheets they provide. Verified customer, UK

Description Cell permeable, reversible adenylyl cyclase activator. Neuronal differentiation inducer. Used in production of liver organoids.
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Fig 1 Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)
Fig 2 Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)
Fig 3 Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)
Forskolin product vial image | Hello Bio

Biological Data

Biological description

Cell permeable, reversible adenylyl cyclase activator which increases cAMP levels and inhibits platelet-activating factor (PAF).

Inhibits mast cell degranulation and lowers intraocular pressure. Also displays vasodilating and hypotensive properties.

It is used as a neuronal differentiation inducer, used as a 3D Growth matrix component and used in the production of liver organoids. Forskolin, in combination with the 2i inhibitors (CHIR 99021 & PD 0325901), and LIF is sufficient to transform hESCs to a naive, mouse embryonic-like state.


Application notes

Figures 1 - 3 show liver hepatocellular carcinoma tumouroids cultured with forskolin and A 83-01

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (25 mM)

Cell culture media can be prewarmed before adding the compound to avoid potential precipitation of the compound.

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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More Info

Chemical Data

Purity >98%
Chemical name [3R-(3<α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
Molecular Weight 410.51
Chemical structure Forskolin  [66575-29-9] Chemical Structure
Molecular Formula C22H34O7
CAS Number 66575-29-9
PubChem identifier 47936
SMILES CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O
InChi InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
MDL number MFCD00082317

References for Forskolin

References are publications that support the biological activity of the product
  • Forskolin and derivatives as tools for studying the role of cAMP.

    Alasbahi RH et al (2012) Pharmazie 67(1) : 5-13.
  • Forskolin: upcoming antiglaucoma molecule.

    Wagh VD et al (2012) J Postgrad Med 58(3) : 199-202.
  • Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling.

    Insel PA et al (2003) Cell Mol Neurobiol 23(3) : 305-14.
  • Interactions of forskolin and adenylate cyclase. Effects on substrate kinetics and protection against inactivation by heat and N-ethylmaleimide.

    Awad JA et al (1983) J Biol Chem 258(5) : 2960-5.

4 Item(s)

These publications cite the use of Forskolin purchased from Hello Bio:
  • In vitro modelling of human microglial alterations associated with Alzheimer's disease and polygenic risk

    Salis et al (2022) Cardiff University : Thesis
  • TRV130 partial agonism and capacity to induce anti-nociceptive tolerance revealed through reducing available μ-opioid receptor number

    Singleton S et al (2021) Br J Pharmacol 178(8) : 1855-1868
    PubMedID: 33555037
  • Differential regulation of prelimbic and thalamic transmission to the basolateral amygdala by acetylcholine receptors

    Mott et al (2021) bioRxiv https://doi.org/10.1101/2021.12.28.474396 : doi
  • The residence of synaptically released dopamine on D2 autoreceptors

    Condon AF et al (2021) Cell Rep 36(5) : 109465
    PubMedID: 34348146
  • Chemical Stimulation of Rodent and Human Cortical Synaptosomes: Implications in Neurodegeneration

    Ahmad et al (2021) Cells 10(5) : 1174

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