Forskolin

(HB1348)
Technical documents: SDS CoA Datasheet

Product overview

Name Forskolin
Description Cell permeable, reversible adenylyl cyclase activator. Neuronal differentiation inducer. Used in production of liver organoids.
Purity >98%
Customer comments

I am currently working with forskolin. The quality of product and service is very satisfying. I am very happy to have access to your high quality products. Pojeong Park, PhD student, University of Bristol, UK

Very satisfied with this product, it works as expected in our liver tumouroid cultures. Hello Bio are a fantastic company that keep you informed of your order throughout the delivery process. Also a fan of the datasheets they provide. Verified customer, UK

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Images

Forskolin: Scientist Approved
Forskolin vial
Fig 1 Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)
Fig 2 Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)
Fig 3 Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)
Forskolin product vial image | Hello Bio

Biological Data

Biological description

Cell permeable, reversible adenylyl cyclase activator which increases cAMP levels and inhibits platelet-activating factor (PAF).

It also inhibits mast cell degranulation and lowers intraocular pressure.

It is used as a neuronal differentiation inducer. It is also used as a 3D Growth matrix component and used in production of liver organoids.

Also displays vasodilating and hypotensive properties.

Application notes

Figures 1 - 3 show liver hepatocellular carcinoma tumouroids cultured with forskolin and A 83-01

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (25 mM)
Handling

Cell culture media can be prewarmed before adding the compound to avoid potential precipitation of the compound.

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name [3R-(3<α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
Molecular Weight 410.51
Chemical structure Forskolin  [66575-29-9] Chemical Structure
Molecular Formula C22H34O7
CAS Number 66575-29-9
PubChem identifier 47936
SMILES CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O
InChi InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
InChiKey OHCQJHSOBUTRHG-KGGHGJDLSA-N
MDL number MFCD00082317

References for Forskolin

References are publications that support the biological activity of the product
  • Forskolin and derivatives as tools for studying the role of cAMP.

    Alasbahi RH et al (2012) Pharmazie 67(1) : 5-13.
  • Forskolin: upcoming antiglaucoma molecule.

    Wagh VD et al (2012) J Postgrad Med 58(3) : 199-202.
  • Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling.

    Insel PA et al (2003) Cell Mol Neurobiol 23(3) : 305-14.
  • Interactions of forskolin and adenylate cyclase. Effects on substrate kinetics and protection against inactivation by heat and N-ethylmaleimide.

    Awad JA et al (1983) J Biol Chem 258(5) : 2960-5.
Publications
These publications cite the use of Forskolin purchased from Hello Bio:
  • Chemical Stimulation of Rodent and Human Cortical Synaptosomes: Implications in Neurodegeneration

    Ahmad et al (2021) Cells 10(5) : 1174
  • The readily-releasable pool dynamically regulates multivesicular release

    Vaden et al (2019) eLife : 8
    PubMedID: 31364987

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