Organoids

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Organoids are 3D tissue/organ models made up of pluripotent stem cells and other supporting co-cultured cells eg. epithelial cells. Many types of organoids have been developed to date, including brain, pancreas, heart, lung, intestine, liver, optic cup and cancer organoids. They make stable model systems and can be derived from human stem cells or from patient derived iPSCs. Small molecules are increasingly being used to grow and maintain organoids because of their ease of use and controllable quality, enabling consistent, repeatable results. Researchers can save up to 50% on high purity small molecules used to generate organoids – the range from Hello Bio is around half the price of other suppliers.

9 Items

Set Descending Direction
  1. CHIR 99021 (HB1261)

    Description:

    Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $48
    Qty:
    Pack:
    2mg
    Price:
    Qty:
    Pack:
    5×2mg
    Price:
    $180
    Qty:
    Pack:
    10mg
    Price:
    $175
    Qty:
    Pack:
    5mg
    Price:
    $112
    Qty:
    Pack:
    25mg
    Price:
    $427
    Qty:
    Pack:
    50mg
    Price:
    $727
    Qty:
    Pack:
    10mM (1mL in DMSO)
    Price:
    $121
    Qty:
  2. Description:

    Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons. Water soluble.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $220
    Qty:
    Pack:
    50mg
    Price:
    $879
    Qty:
  3. DAPT (HB3345)

    1  Review
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    Description:

    γ-secretase inhibitor and classical notch inhibitor. Induces neuronal differentiation. 3D Growth matrix component and used in cerebral organoid differentiation media.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    Qty:
    Pack:
    10mg
    Price:
    $168
    Qty:
    Pack:
    25mg
    Price:
    $418
    Qty:
    Pack:
    50mg
    Price:
    $703
    Qty:
    Pack:
    10mM (1mL in DMSO)
    Price:
    $109
    Qty:
  4. IWP 2 (HB0344)

    Description:

    Potent Wnt pathway inhibitor and PORCN inhibitor. Suppresses R1 ESC self-renewal. Used in the production of cardiac organoids.

    Purity:

    >98%

    Pack:
    25mg
    Price:
    $359
    Qty:
  5. IWP 4 (HB3066)

    Description:

    Potent Wnt/β-catenin signaling inhibitor. Induces cardiomyocyte differentiation of hESCs and iPSCs.

    Purity:

    >98%

    Pack:
    25mg
    Price:
    $534
    Qty:
  6. PD 0325901 (HB2240)

    Description:

    Potent MEK1 and MEK2 inhibitor. Enhances iPSCs generation. Used in organoid production.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    Qty:
    Pack:
    2mg
    Price:
    $28
    Qty:
    Pack:
    5×2mg
    Price:
    $115
    Qty:
    Pack:
    10mg
    Price:
    $109
    Qty:
    Pack:
    50mg
    Price:
    $308
    Qty:
  7. SB 202190 (HB1301)

    Description:

    Potent ATP competitive p38 MAPK inhibitor. 3D growth matrix component, promotes long-term organoid growth and can be used in production of gastric organoids. Promotes stability of human pluripotent stem cells.

    Purity:

    >99%

    Pack:
    5mg
    Price:
    $87
    Qty:
    Pack:
    10mg
    Price:
    $131
    Qty:
    Pack:
    25mg
    Price:
    $325
    Qty:
    Pack:
    50mg
    Price:
    $547
    Qty:
  8. SB 431542 (HB3555)

    4  Reviews
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    Description:

    Potent, selective TGF-βRI ALK5, ALK4, ALK7 inhibitor. Induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells and replaces SOX2 in reprogramming protocols.3D growth matrix component and can be used in production of organoids.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $109
    Qty:
    Pack:
    5mg
    Price:
    $153
    Free trial
    Qty:
    Pack:
    2x5mg
    Price:
    $240
    Qty:
    Pack:
    10mg
    Price:
    $233
    Qty:
    Pack:
    25mg
    Price:
    $508
    Qty:
    Pack:
    50mg
    Price:
    $959
    Qty:
    Pack:
    10mM (1mL in DMSO)
    Price:
    $154
    Qty:
  9. 6  Reviews
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    Description:

    Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts.

    Purity:

    >99%

    Pack:
    1mg
    Price:
    $44
    Qty:
    Pack:
    2mg
    Price:
    Qty:
    Pack:
    5mg
    Price:
    $119
    Qty:
    Pack:
    10mg
    Price:
    $168
    Qty:
    Pack:
    5x10mg
    Price:
    $754
    Qty:
    Pack:
    25mg
    Price:
    $325
    Qty:
    Pack:
    50mg
    Price:
    $564
    Qty:
    Pack:
    10mM solution (in 1mL DMSO)
    Price:
    $172
    Qty: