Product overview
| Name | PD 0325901 |
| Description | Potent MEK1 and MEK2 inhibitor. Enhances iPSCs generation. Used in organoid production. |
| Alternative names | PD325901 |
| Purity | >98% |
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Biological Data
| Biological description | PD 0325901 is a potent, non-ATP competitive MEK1 (MKK1) and MEK2 (MKK2) inhibitor (Ki values are 0.79 and 1.1 nM at MEK1 and MEK2 respectively). Cell permeable. PD 0325901 induces G1-phase cell cycle arrest and apoptosis and inhibits melanoma cell line growth in vitro and in vivo. It increases reprogramming efficiency of human primary fibroblasts into iPSCs when combined with SB 431542 and also prevents cell differentiation and sustains self-renewal of ESCs when combined with CHIR 99021. Used in ear organoid production. |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in DMSO (25mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | N-[(2R)-2,3-Dihydroxypropoxy]-3,4-d ifluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide |
| Molecular Weight | 482.19 |
| Chemical structure | ![PD 0325901 | PD325901 [391210-10-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb2240.png "PD 0325901 | PD325901 [391210-10-9]") |
| Molecular Formula | C16H14F3IN2O4 |
| CAS Number | 391210-10-9 |
| PubChem identifier | 9826528 |
| SMILES | C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOC[C@@H](CO)O |
| InChi | InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1 |
| InChiKey | SUDAHWBOROXANE-SECBINFHSA-N |
| MDL number | MFCD08435926 |
| Appearance | White Solid |
References for PD 0325901
References are publications that support the biological activity of the product
-
A chemical platform for improved induction of human iPSCs.
Lin et al (2009) Nat Methods 6(11) : 805-8 -
Growth-inhibitory and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations.
Ciuffreda et al (2009) Neoplasia 11(8) : 720-31. -
The ground state of embryonic stem cell self-renewal.
Ying et al (2008) Nature 453(7194) : 519-23 -
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
Barrett et al (2008) Bioorg Med Chem Lett 18(24) : 6501-4.
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