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PD 0325901

(HB2240)
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Technical documents: SDS CoA Datasheet

Product overview

Name PD 0325901
Alternative names PD325901
Purity >98%
Description Potent MEK1 and MEK2 inhibitor. Enhances iPSCs generation. Used in organoid production.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4) Frequently bought together
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Biological Data

Biological description

PD 0325901 is a potent, non-ATP competitive MEK1 (MKK1) and MEK2 (MKK2) inhibitor (Ki values are 0.79 and 1.1 nM at MEK1 and MEK2 respectively).

Cell permeable.

PD 0325901 induces G1-phase cell cycle arrest and apoptosis and inhibits melanoma cell line growth in vitro and in vivo.

It increases reprogramming efficiency of human primary fibroblasts into iPSCs when combined with SB 431542 and also prevents cell differentiation and sustains self-renewal of ESCs when combined with CHIR 99021 (as part of the 2i inhibitor combination).

Also used in ear organoid production.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (25mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name N-[(2R)-2,3-Dihydroxypropoxy]-3,4-d ifluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
Molecular Weight 482.19
Chemical structure PD 0325901 | PD325901 [391210-10-9] Chemical Structure
Molecular Formula C16H14F3IN2O4
CAS Number 391210-10-9
PubChem identifier 9826528
SMILES C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOC[C@@H](CO)O
InChi InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
InChiKey SUDAHWBOROXANE-SECBINFHSA-N
MDL number MFCD08435926
Appearance White Solid

References for PD 0325901

References are publications that support the biological activity of the product

  • A chemical platform for improved induction of human iPSCs.

    Lin et al (2009) Nat Methods 6(11) : 805-8
    Read more (PubMedID: 19838168)

  • Growth-inhibitory and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations.

    Ciuffreda et al (2009) Neoplasia 11(8) : 720-31.
    Read more (PubMedID: 19649202)

  • The ground state of embryonic stem cell self-renewal.

    Ying et al (2008) Nature 453(7194) : 519-23
    Read more (PubMedID: 18497825)

  • The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.

    Barrett et al (2008) Bioorg Med Chem Lett 18(24) : 6501-4.
    Read more (PubMedID: 18952427)

4 Item(s)

Related Products
Grouped product items
Order: HB2240
Pack PriceQty
1mg
$19
2mg
$25
10mg
$99
50mg
$280
Potent MEK1 and MEK2 inhibitor. Enhances iPSCs generation. Used in organoid production.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com

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