PD 0325901 is a potent, non-ATP competitive MEK1 (MKK1) and MEK2 (MKK2) inhibitor (Ki values are 0.79 and 1.1 nM at MEK1 and MEK2 respectively).
PD 0325901 induces G1-phase cell cycle arrest and apoptosis and inhibits melanoma cell line growth in vitro and in vivo.
It increases reprogramming efficiency of human primary fibroblasts into iPSCs when combined with SB 431542 and also prevents cell differentiation and sustains self-renewal of ESCs when combined with CHIR 99021 (as part of the 2i inhibitor combination).
Also used in ear organoid production.
Solubility & Handling
Soluble in DMSO (25mM)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.