PI3K/Akt/mTOR

Novel, selective Piezo1 channel activator. Improved efficacy and potency compared to Yoda1.

Potent endothelin receptor antagonist

Potent CDK inhibitor. Also GSK-3 inhibitor. Generates iPSCs.

Selective 5-HT₂ receptor antagonist

Selective CaM kinase II inhibitor. P2X₇ receptor antagonist.

Potent CaM kinase II inhibitor

Potent, selective PKA inhibitor

Potent, selective PKG inhibitor

Potent, selective mTOR inhibitor

Wnt signaling inhibitor. Promotes differentiation of hESCs and iPSCs into cardiomyocytes.