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KN-93 phosphate (water soluble)

(HB0360)
Publications (2)
Technical documents: SDS Datasheet
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Product overview

Name KN-93 phosphate (water soluble)
Purity >98%
Description Potent CaM kinase II inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews Publications (2) Frequently bought together
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KN-93 phosphate (water soluble) product vial image | Hello Bio
KN-93 phosphate (water soluble) product vial image | Hello Bio

KN-93 phosphate (water soluble) product vial image | Hello Bio

KN-93 phosphate (water soluble) product vial image | Hello Bio

Biological Data

Biological description Potent CaM kinase II inhibitor (IC50 = 0.37 µM). Also acts as a direct, extracellular voltage-gated K+ channels blocker (IC50 = 307 nM at Kv1.5 channels) in a manner which is independent of CaMKII. KN-93 may act via promotion and stabilization of C-type inactivation.

Solubility & Handling

Solubility overview Soluble in water
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4 -methoxybenzenesulphonamide phosphate
Molecular Weight 501
Chemical structure KN-93 [1188890-41-6] Chemical Structure
Molecular Formula C26H29ClN2O4S.H33PO4
CAS Number 1188890-41-6
PubChem identifier 16760530
SMILES CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC
InChiKey LLLQTDSSHZREGW-AATRIKPKSA-N
Publications
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These publications cite the use of KN-93 phosphate (water soluble) purchased from Hello Bio:

  • Impaired State-Dependent Potentiation of GABAergic Synaptic Currents Triggers Seizures in a Genetic Generalized Epilepsy Model

    Zhang CQ et al (2021) Cereb Cortex 31(2) : 768-784
    PubMedID: 32930324

  • Impaired state-dependent potentiation of GABAergic synaptic currents triggers seizures in an idiopathic generalized epilepsy model

    Zhou et al (2020) bioRxiv https://doi.org/10.1101/2020.05.10.087114 : doi

2 Item(s)

Grouped product items
Order: HB0360
Pack PriceQty
1mg
$193
Potent CaM kinase II inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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