KT 5823

Name: KT 5823
SKU: HB1316
Price: 127 USD
Availability: InStock

(HB1316)

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Technical documents: SDS Datasheet

Product overview

Name

KT 5823

Purity

>98%

Description

Potent, selective PKG inhibitor

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) References (3) Frequently bought together

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Biological Data

Biological description

Potent and selective protein kinase G (PKG) inhibitor (K_i = 0.234 µM). Exhibits selectivity for PKG over PKA and PKC (K_i values are >10.0 and 4.0 µM for PKA and PKC respectively). Arrests cell cycle at G_O/G₁ boundary and also modulates Na⁺/I^- symporter (NIS). Displays pro-apoptotic properties.

Solubility & Handling

Storage instructions

-20°C (desiccate)

Solubility overview

Soluble in DMSO (50mM)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>98%

Chemical name

(9S,10R,12R)-2,3,9,10,11,12-Hexahyd ro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-dii ndolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodi azocine-10-carboxylic acid, methyl ester

Molecular Weight

495.53

Molecular Formula

C₂₉H₂₅N₃O₅

CAS Number

126643-37-6

PubChem identifier

108152

SMILES

[H][C@]18O[C@](N6C4=C3N1C2=CC=CC=C2C3=C7C(CN(C7=O)C)=C4C5=CC=CC=C56)([C@]([C@@](OC)=O)(OC)C8)C

InChiKey

QTYMDECKVKSGSM-YMUMJAELSA-N

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for KT 5823

References are publications that support the biological activity of the product

KT5823 differentially modulates sodium iodide symporter expression, activity, and glycosylation between thyroid and breast cancer cells.
Beyer S et al (2011) Endocrinology 152(3) : 782-92.
Read more (PubMedID: 21209020)
Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG.
Chan SL et al (2003) Mol Hum Reprod 9(12) : 775-83.
Read more (PubMedID: 14614039)
Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells.
Gadbois DM et al (1992) Proc Natl Acad Sci U S A 89(18) : 8626-30.
Read more (PubMedID: 1528872)

Potent, selective PKG inhibitor

Order: HB1316
Pack	Price	Qty
50μg	$127
250μg	$502

KT 5823

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for KT 5823

KT5823 differentially modulates sodium iodide symporter expression, activity, and glycosylation between thyroid and breast cancer cells.

Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG.

Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells.

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KT 5823

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for KT 5823

KT5823 differentially modulates sodium iodide symporter expression, activity, and glycosylation between thyroid and breast cancer cells.

Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG.

Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells.

About you

Tell us about your publication!

Captcha

About you

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New Products in this Area