Potent and selective protein kinase G (PKG) inhibitor (Ki = 0.234 µM). Exhibits selectivity for PKG over PKA and PKC (Ki values are >10.0 and 4.0 µM for PKA and PKC respectively). Arrests cell cycle at GO/G1 boundary and also modulates Na+/I- symporter (NIS). Displays pro-apoptotic properties.
Solubility & Handling
Solubility overview
Soluble in DMSO (50mM)
Storage instructions
-20°C (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG.
Chan SL et al (2003) Mol Hum Reprod 9(12) : 775-83.
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