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Images KT 5720: Scientist Approved
KT 5720 product vial image | Hello Bio
KT 5720: Scientist Approved KT 5720 product vial image | Hello Bio Biological Data Biological description Potent and selective protein kinase A inhibitor (Ki = 60 nM). Arrests skin fibroblasts in the G1 stage. Reverses multi-drug resistance in leukaemia and attenuates hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the dorsal root ganglion (DRG). Cell-permeable.
Solubility & Handling Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO and in methanol
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (9R ,10S ,12S )-2,3,9,10,11,12-Hexahyd ro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H -diindolo[1,2,3-fg :3',2',1'-kl ]pyrrolo[3,4-i ][1,6]benzodiazocine-10-carboxylic acid, hexyl ester
Chemical structure
Molecular Formula C32 H31 N3 O5
SMILES CCCCCCOC(=O)C1(CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C7=C53)C1(O2)C)CNC6=O)O
InChi InChI=1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)
InChiKey ZHEHVZXPFVXKEY-UHFFFAOYSA-N
References for KT 5720 References are publications that support the biological activity of the product
Novel role of KT5720 on regulating hyperpolarization-activated cyclic nucleotide-gated channel activity and dorsal root ganglion neuron excitability. Cheng Q et al (2013) DNA Cell Biol 32(6) : 320-8. In vitro and in vivo reversal of MDR1-mediated multidrug resistance by KT-5720: implications on hematological malignancies. Galski H et al (2006) Leuk Res 30(9) : 1151-8. Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. Gadbois DM et al (1992) Proc Natl Acad Sci U S A 89(18) : 8626-30. K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Kase H et al (1987) Biochem Biophys Res Commun 142(2) : 436-40.
Publications
These publications cite the use of KT 5720 purchased from Hello Bio:
Cortical potentiation induced by calcitonin gene-related peptide (CGRP) in the insular cortex of adult mice Liu Y et al (2020) Mol Brain 13(1) : 36 Investigating the Role of LIMK1 Signaling in PKA-dependent LTP in the Hippocampus Cai, S. (2019) University of Toronto Thesis : 1-135
On the Role of Calcium-Permeable AMPARs in Long-Term Potentiation and Synaptic Tagging in the Rodent Hippocampus. Park et al (2019) Front Synaptic Neurosci. 14; : 11:4 Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus. Park et al (2016) J Neurosci 36(2) : 622-31
Potent, selective PKA inhibitor
![KT 5720 [108068-98-0] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0361.png "KT 5720 [108068-98-0]")
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