Cytoskeleton and Extracellular Matrix
The cytoskeleton acts as a cellular scafforld within a cell and plays an important role in many processes such as cell motility and cell division. Many cytoskeletal proteins interact with proteins of the extracellular matrix (ECM). The ECM is a network of extracellular molecules which provide structural and biochemical support to surrounding. The ECM is vital to cellular processes including proliferation, adhesion, migration, polarity, differentiation, and apoptosis.
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View products: Actin | Matrix Metalloproteases (MMP) | PI3K/Akt/mTOR | Microtubule | ROCK (Rho-kinase)
SAG (HB3107)
Description:Cell permeable Sonic hedgehog (Shh) agonist and Smo agonist. Enhances neuronal differentiation of iPSC into dopaminergic neurons.
Purity:>98%
SB 202190 (HB1301)
Description:Potent ATP competitive p38 MAPK inhibitor. 3D growth matrix component, promotes long-term organoid growth and can be used in production of gastric organoids. Promotes stability of human pluripotent stem cells.
Purity:>99%
SB 431542 (HB3555)
Description:Potent, selective TGF-βRI ALK5, ALK4, ALK7 inhibitor. Induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells and replaces SOX2 in reprogramming protocols.3D growth matrix component and can be used in production of organoids.
Purity:>98%
Sodium butyrate (HB1399)
Description:HDAC inhibitor. Directs mESC differentiation into hepatocytes.
SP600125 (HB2234)
Description:Selective, ATP-competitive JNK inhibitor. Prevents BMP9-induced osteogenic MSC differentiation. Maintains stem cells in naive pluripotent state.
Purity:>98%
Stauprimide (HB3011)
Description:NME2 nuclear translocation inhibitor. Primes ESCs for differentiation.
Purity:>98%
Strontium chloride (HB3424)
Description:Calcium sensing receptor (CaSR) agonist. Induces MSC osteogenic differentiation.
SU 5402 (HB3133)
Description:Potent FGFR and VEGFR inhibitor. Attenuates integrin β4-induced neural stem cell differentiation.
Purity:>95%
T3 (triiodothyronine) (HB7470)
Description:Thyroid hormone. Frequently used in various stem cell protocols.
Purity:>98%
Venlafaxine hydrochloride (HB1743)
Description:Serotonin/norepinephrine re-uptake inhibitor. Affects differentiation of NSCs.
Purity:>98%