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SB 431542

Technical documents: SDS CoA Datasheet

Product overview

Name SB 431542
Purity >98%
Description Potent, selective TGF-βRI ALK5, ALK4, ALK7 inhibitor. Induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells and replaces SOX2 in reprogramming protocols.3D growth matrix component and can be used in production of organoids.
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Biological Data

Biological description

Potent and selective transforming growth factor β type I receptor (TGF-βRI) actvin receptor-like kinase ALK5, ALK4 and ALK7 inhibitor (IC50 = 94 nM at ALK5).

Specifically inhibits Smad2/3 activation and blocks TGF-β signal transduction.

Maintains the undifferentiated state of mouse embryonic stem cells (ESCs).

Also induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells.

It additionally can be used as a 3D growth matrix component and can be used in production of organoids (e.g. brain/ blood vessel organoids).

It can also be used to replace the SOX2 factor in reprogramming protocols.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM) and ethanol (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide
Molecular Weight 384.4
Chemical structure SB 431542 [301836-41-9] Chemical Structure
Molecular Formula C22H16N4O3
CAS Number 301836-41-9
PubChem identifier 4521392
SMILES C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
Source Synthetic
InChi InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
MDL number MFCD11045982
Appearance Yellow solid

References for SB 431542

References are publications that support the biological activity of the product
  • Mechanism of SB431542 in inhibiting mouse embryonic stem cell differentiation.

    Du et al (2014) Cell Signal 26(10) : 2107-16
  • TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells.

    Watabe et al (2003) J Cell Biol 163(6) : 1303-11
  • Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.

    Laping et al (2002) Mol Pharmacol 62(1) : 58-64
  • SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I ALK receptors ALK4, ALK5, and ALK7.

    Inman et al (2002) Mol Pharmacol 62(1) : 65-74

4 Item(s)

These publications cite the use of SB 431542 purchased from Hello Bio:
  • Modeling early neuronal development in Kabuki Syndrome using human induced pluripotent stem cells.

    Kilpinen et al (2022) Thesis
  • Epithelial folding of alveolar cells derived from human induced pluripotent stem cells on artificial basement membrane.

    Rofaani E et al (2022) Acta biomaterialia
    PubMedID: 35306184
  • In vitro modelling of human microglial alterations associated with Alzheimer's disease and polygenic risk

    Salis et al (2022) Cardiff University : Thesis

3 Item(s)