Potent, selective TGF-βRI ALK5, ALK4, ALK7 inhibitor. Induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells and replaces SOX2 in reprogramming protocols.3D growth matrix component and can be used in production of organoids.
Potent and selective transforming growth factor β type I receptor (TGF-βRI) actvin receptor-like kinase ALK5, ALK4 and ALK7 inhibitor (IC50 = 94 nM at ALK5).
Specifically inhibits Smad2/3 activation and blocks TGF-β signal transduction.
Maintains the undifferentiated state of mouse embryonic stem cells (ESCs).
Also induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells.
It additionally can be used as a 3D growth matrix component and can be used in production of organoids (e.g. brain/ blood vessel organoids).
It can also be used to replace the SOX2 factor in reprogramming protocols.
Solubility & Handling
Storage instructions
Room temperature
Solubility overview
Soluble in DMSO (100mM) and ethanol (10mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.
Potent, selective TGF-βRI ALK5, ALK4, ALK7 inhibitor. Induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells and replaces SOX2 in reprogramming protocols.3D growth matrix component and can be used in production of organoids.
![SB 431542 [301836-41-9] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb3555.png "SB 431542 [301836-41-9]")
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