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SB 431542

(HB3555)
Publications (5)
Technical documents: SDS CoA Datasheet
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Product overview

Name SB 431542
Purity >98%
Description Potent, selective TGF-βRI ALK5, ALK4, ALK7 inhibitor. Induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells and replaces SOX2 in reprogramming protocols.3D growth matrix component and can be used in production of organoids.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews (4) Publications (5) References (4) Frequently bought together
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Biological Data

Biological description

Potent and selective transforming growth factor β type I receptor (TGF-βRI) actvin receptor-like kinase ALK5, ALK4 and ALK7 inhibitor (IC50 = 94 nM at ALK5).

Specifically inhibits Smad2/3 activation and blocks TGF-β signal transduction.

Maintains the undifferentiated state of mouse embryonic stem cells (ESCs).

Also induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells.

It additionally can be used as a 3D growth matrix component and can be used in production of organoids (e.g. brain/ blood vessel organoids).

It can also be used to replace the SOX2 factor in reprogramming protocols.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM) and ethanol (10mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >98%
Chemical name 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide
Molecular Weight 384.4
Chemical structure SB 431542 [301836-41-9] Chemical Structure
Molecular Formula C22H16N4O3
CAS Number 301836-41-9
PubChem identifier 4521392
SMILES C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
Source Synthetic
InChi InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
InChiKey FHYUGAJXYORMHI-UHFFFAOYSA-N
MDL number MFCD11045982
Appearance Yellow solid

References for SB 431542

References are publications that support the biological activity of the product

  • Mechanism of SB431542 in inhibiting mouse embryonic stem cell differentiation.

    Du et al (2014) Cell Signal 26(10) : 2107-16
    Read more (PubMedID: 24949833)

  • TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells.

    Watabe et al (2003) J Cell Biol 163(6) : 1303-11
    Read more (PubMedID: 14676305)

  • Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.

    Laping et al (2002) Mol Pharmacol 62(1) : 58-64
    Read more (PubMedID: 12065755)

  • SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I ALK receptors ALK4, ALK5, and ALK7.

    Inman et al (2002) Mol Pharmacol 62(1) : 65-74
    Read more (PubMedID: 12065756)

4 Item(s)

Publications
Submit Yours Now
These publications cite the use of SB 431542 purchased from Hello Bio:

  • Parkinson’s associated protein DJ-1 regulates intercellular communication via extracellular vesicles in oxidative stress.

    Page et al (2025) Cellular and Molecular Life Sciences : https://www.researchsquare.com/article/rs-5669239/v1

  • Modeling early neuronal development in Kabuki Syndrome using human induced pluripotent stem cells.

    Kilpinen et al (2022) Thesis

  • Epithelial folding of alveolar cells derived from human induced pluripotent stem cells on artificial basement membrane.

    Rofaani E et al (2022) Acta biomaterialia
    PubMedID: 35306184

  • In vitro modelling of human microglial alterations associated with Alzheimer's disease and polygenic risk

    Salis et al (2022) Cardiff University : Thesis

  • Engineered basement membrane for alveolar and airway epithelia modeling

    Rofaani et al (2022) Thesis (Universite Paris)

5 Item(s)

Related Products
Grouped product items
Order: HB3555
Pack PriceQty
1mg
$114
5mg
$160
2x5mg
$250
10mg
$243
25mg
$530
50mg
$1,000
10mM (1mL in DMSO)
$161
Potent, selective TGF-βRI ALK5, ALK4, ALK7 inhibitor. Induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells and replaces SOX2 in reprogramming protocols.3D growth matrix component and can be used in production of organoids.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

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