Compound repurposing
Small molecule compounds are being studied for repurposing in COVID-19 treament and research. Multiple small molecules that are approved to treat other disorders have shown potential effects on key proteins involved in SARS-CoV-2 host cell entry and replication. Repurposing of existing compounds is advantageous for speed - reducing timescales compared to conventional drug discovery. Researchers can save up to 50% on these small molecules for COVID-19 research, as they are up to half the price of other suppliers.
Recombinant human GDNF protein (HB5735)
Description:Neurotrophin which enhances differentiation and survival of dopaminergic neurons
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Recombinant human NT-3 protein (HB8373)
Description:Neurotrophin involved in neuron development, survival and differentiation
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RepSox (HB3301)
Description:Potent, selective TGF-βRI inhibitor. Enhances cellular reprogramming efficiency.
Purity:>99%
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RG 108 (HB1377)
Description:Non-nucleoside DNA methyltransferase inhibitor. Enhances iPSC generation efficiency.
Purity:>99%
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Rosiglitazone (HB2556)
Description:Potent and selective PPARγ agonist. Promotes adipocyte differentiation and enhances NPC proliferation.
Purity:>99%
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SAG (HB3107)
Description:Cell permeable Sonic hedgehog (Shh) agonist and Smo agonist. Enhances neuronal differentiation of iPSC into dopaminergic neurons.
Purity:>98%
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SB 202190 (HB1301)
Description:Potent ATP competitive p38 MAPK inhibitor. 3D growth matrix component, promotes long-term organoid growth and can be used in production of gastric organoids. Promotes stability of human pluripotent stem cells.
Purity:>99%
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SB 203580 (HB1302)
Description:Potent, selective p38 MAPK inhibitor. Stimulates neural stem cell proliferation.
Purity:>98%
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SB 216763 (HB1272)
Description:Potent, selective cell permeable GSK-3 inhibitor. Maintains mESCs and promotes retinal stem cells proliferation.
Purity:>98%
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SB 431542 (HB3555)
Description:Potent, selective TGF-βRI ALK5, ALK4, ALK7 inhibitor. Induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells and replaces SOX2 in reprogramming protocols.3D growth matrix component and can be used in production of organoids.
Purity:>98%
