Mineralocorticoid

Potent, selective, non-competitive mGlu₁ antagonist

Selective PIEZO1 channel activator

Novel, selective Piezo1 channel activator. Improved efficacy, potency and solubility compared to Yoda1.

Potent 5-HT₃ antagonist and 5-HT₄ agonist. Also selective IK1 channel agonist.

Estrogen receptor agonist

5-HT_2A and D₂ antagonist. Atypical antipsychotic.

Potent, selective A_2A receptor antagonist

Potent 5-HT_1B/1D/1F agonist

Potent, selective Na⁺ / H⁺ exchanger-1 inhibitor

5-HT_2A and dopamine D₂ receptor antagonist. Atypical antipsychotic.