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Zoniporide dihydrochloride

(HB1137)
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Product overview

Name Zoniporide dihydrochloride
Alternative names CP 597396
Purity >99%
Description Potent, selective Na+ / H+ exchanger-1 inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Potent and selective Na+/H+ exchanger-1 (NHE-1) inhibitor (IC50 = 14 nM). Exhibits 157- fold and 15,700- fold selectivity for NHE1 over human NHE-2 and rat NHE-3 respectively. Displays cardioprotective properties and reduces both the incidence and duration of ischemia-reperfusion.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (10mM) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name [1-(Quinolin-5-yl)-5-cyclopropyl-1H -pyrazole-4-carbonyl]guanidine dihydrochloride
Molecular Weight 393.27
Chemical structure Zoniporide dihydrochloride [241799-10-0] Chemical Structure
Molecular Formula C17H16N6O.2HCl
CAS Number 241799-10-0
PubChem identifier 22267855
SMILES O=C(/N=C(N)/N)C(C=N3)=C(C4CC4)N3C1=C2C(N=CC=C2)=CC=C1.Cl.Cl
InChiKey ARZNPJAGKWHEHT-UHFFFAOYSA-N

References for Zoniporide dihydrochloride

References are publications that support the biological activity of the product

  • [Cardioprotective properties of zoniporide studied on experimental ischemia and reperfusion models in rat myocardium].

    Gurova NA et al (2013) Eksp Klin Farmakol 76(8) : 17-9.
    Read more (PubMedID: 24228483)

  • Zoniporide: a potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1).

    Tracey WR et al (2003) Cardiovasc Drug Rev 21(1) : 17-32.
    Read more (PubMedID: 12595915)

  • Zoniporide: a potent and highly selective inhibitor of human Na(+)/H(+) exchanger-1.

    Marala RB et al (2002) Eur J Pharmacol 451(1) : 37-41.
    Read more (PubMedID: 12223226)

3 Item(s)

Grouped product items
Order: HB1137
Pack PriceQty
10mg
$210
50mg
$844
Potent, selective Na+ / H+ exchanger-1 inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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