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Yoda2 (KC289)

(HB9134)
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Technical documents: CoA Datasheet

Product overview

Name Yoda2 (KC289)
Description

Novel, selective Piezo1 channel activator. Improved efficacy, potency and solubility compared to Yoda1.

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (2) Frequently bought together
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Biological Data

Biological description

Novel, selective Piezo1 channel activator which shows improved (or equivalent) reliability, efficacy and potency in functional assays compared to Yoda1 (EC50 values are 150nM and 600nM at mouse Piezo1 in calcium assays for Yoda2 (KC289) and Yoda1 respectively). Selective for Piezo1 over other membrane proteins and suggested to have greater effect and potency at mouse Piezo1 compared to human Piezo1. Also shows improved aqueous solubility more suited to physiological conditions than those of Yoda1 (~160x more soluble in aqueous buffer than Yoda1). Active in vivo and shows vasorelaxant effects consistent with Piezo1 agonism.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Chemical name 4-(5-{[(2,6-dichlorophenyl)methyl]sulfanyl}-1,3,4-thiadiazol-2-yl)benzoic acid potassium salt
Molecular Weight 435.39
Chemical structure Chemical Structure
Molecular Formula C16H9Cl2KN2O2S2
SMILES O=C(O[K])c1ccc(cc1)c1nnc(SCc2c(Cl)cccc2Cl)s1
Source Synthetic
InChi InChI=1S/C16H10Cl2N2O2S2.K/c17-12-2-1-3-13(18)11(12)8-23-16-20-19-14(24-16)9-4-6-10(7-5-9)15(21)22;/h1-7H,8H2,(H,21,22);/q;+1/p-1
InChiKey OQEIWUHZUPFUQU-UHFFFAOYSA-M
Appearance Beige solid

References for Yoda2 (KC289)

References are publications that support the biological activity of the product

  • Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1.

    Parsonage G et al (2023) British journal of pharmacology 180 : 2039-2063
    Read more (PubMedID: 36457143)

  • Independent endothelial functions of PIEZO1 and TRPV4 in hepatic portal vein and predominance of PIEZO1 in mechanical and osmotic stress.

    Endesh N et al (2023) Liver international : official journal of the International Association for the Study of the Liver 43 : 2026-2038
    Read more (PubMedID: 37349903)

2 Item(s)

Related Products
Grouped product items
Order: HB9134
Pack PriceQty
10mg
$156
50mg
$651

Novel, selective Piezo1 channel activator. Improved efficacy, potency and solubility compared to Yoda1.

Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

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