ZM 241385 is a potent, selective adenosine A2A receptor inverse agonist (Ki values are <1, 50, 255 nM and >10 µM at A2A, A2B, A1 and A3 receptors respectively).
The crystal structure of the human A2A receptor was determined in complex with ZM 241385.
Activation of the A2A receptor enhances the release of glutamate, dopamine and acetylcholine and also inhibits GABA release.
The A2AR has been shown to interact with various receptors including the mGlu5, D2R, A1R and CB1 receptors.
A2A receptor activation modulates synaptic plasticity and neuronal excitability.
ZM 241385 is active in vivo.
Solubility & Handling
Solubility overview
Soluble in DMSO (100 mM) and in ethanol (5 mM)
Storage instructions
Room temperature
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
![ZM 241385 [139180-30-6] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb2096.png "ZM 241385 [139180-30-6]")
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