Product overview

Name ZM 241385
Alternative names ZM241385
Purity >99%
Description Potent, selective A2A receptor antagonist
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Biological Data

Biological description

ZM 241385 is a potent, selective adenosine A2A receptor inverse agonist (Ki values are <1, 50, 255 nM and >10 µM at A2A, A2B, A1 and A3 receptors respectively).

The crystal structure of the human A2A receptor was determined in complex with ZM 241385.

Activation of the A2A receptor enhances the release of glutamate, dopamine and acetylcholine and also inhibits GABA release.

The A2AR has been shown to interact with various receptors including the mGlu5, D2R, A1R and CB1 receptors.

A2A receptor activation modulates synaptic plasticity and neuronal excitability.

ZM 241385 is active in vivo.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM) and in ethanol (5 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >99%
Chemical name 4-(2-[7-Amino-2-(2-furyl)[1,2,4]tri azolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol
Molecular Weight 337.34
Chemical structure ZM 241385 [139180-30-6] Chemical Structure
Molecular Formula C16H15N7O2
CAS Number 139180-30-6
PubChem identifier 176407
Source Synthetic
InChi InChI=1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22)
MDL number MFCD00908394
Appearance White solid

References for ZM 241385

References are publications that support the biological activity of the product
  • Adenosine A(2A) receptors in psychopharmacology: modulators of behavior, mood and cognition.

    Shen and Chen (2009) Curr Neuropharmacol. 7(3) : 195-206
  • The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist.

    Jaakola et al (2008) Science 322 (5905) : 1211-7
  • Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors.

    Ongini et al (1999) Naunyn Schmiedebergs Arch Pharmacol. 359(1) : 7-10
  • In vivo characterisation of ZM 241385, a selective adenosine A2A receptor antagonist.

    Keddie et al (1996) Eur J Pharmacol 301(1-3) : 107-13
  • The in vitro pharmacology of ZM 241385, a potent, non-xanthine A2a selective adenosine receptor antagonist.

    Poucher et al (1995) Br J Pharmacol 115(6) : 1096-102

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