Group I (mGlu5, mGlu1)
Group I metabotropic glutamate receptors (mGlu1, mGlu5) are coupled with phospholipase C (PLC) via Gq proteins; activation causes increased levels of IP3 and diacylglycerol, with intracellullar Ca2+ release and protein kinase C (PKC) activation. Group I receptors are predominantly located post synaptically. Researchers can save 50% on group I metabotropic glutamate receptor agonists, antagonists, positive allosteric modulators (PAMs) and negative allosteric modulators (NAMs) from Hello Bio - they are up to half the price of other suppliers.
IEM-1460 (HB0338)
Description:Competitive, selective, GluA2 (GluR2)-lacking AMPA receptor blocker
Purity:>98%
Ifenprodil (HB0339)
Description:Non-competitive GluN2B subunit selective NMDAR allosteric inhibitor
Purity:>99%
Imatinib mesylate (HB1943)
Description:Tyrosine kinase inhibitor that targets BCR‑ABL, c‑KIT, and PDGFR kinases
Purity:>98%
Indole-3-acetamide (HB0341)
Description:Competitive Tryptophan 2-monooxygenase oxidase inhibitor
Purity:>98%