Ifenprodil is a non-competitive, voltage-independent GluN2B subunit selective NMDA receptor allosteric inhibitor (IC50 = 0.15 μM).
It is selective over GluN2A (NR2A), GluN2C (NR2C) and GluN2D (NR2D) subunits (IC50 values are >30 μM).
Ifenprodil is thought to bind at the interface of the GluN1/2B NTD (ATD) (N-terminal domain).
Ifenprodil is commonly used to distinguish between GluN2B- and GluN2A- containing NMDARs in synaptic and extrasynaptic membranes.
Ifenprodil also shows use dependence in which binding of glutamate increases binding of ifenprodil and vice versa.
Shows neuroprotective effects and protects neurons against glutamate excitotoxicity in an activity-dependent manner.
Solubility & Handling
Solubility overview
Soluble in water (15mM, gentle warming)
Storage instructions
Room temperature
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
![Ifenprodil [23210-58-4] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0339.png "Ifenprodil [23210-58-4]")
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