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(-)-Indolactam V

(HB0002)
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Product overview

Name (-)-Indolactam V
Purity >99%
Description Synthetic PKC activator
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4)
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Biological Data

Biological description Synthetic protein kinase C (PKC) inhibitor. Also induces embryonic stem cell differentiation. Displays tumor promoting properties with mitogenic and comitogenic activating effects.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name (2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one
Molecular Weight 301.38
Chemical structure (-)-Indolactam V [90365-57-4] Chemical Structure
Molecular Formula C17H23N3O2
CAS Number 90365-57-4
SMILES CC(C)[C@@H]1N(C)c2cccc3[nH]cc(C[C@@H](CO)NC1=O)c23

References for (-)-Indolactam V

References are publications that support the biological activity of the product

  • A small molecule that directs differentiation of human ESCs into the pancreatic lineage.

    Chen S et al (2009) Nat Chem Biol 5(4) : 258-65.
    Read more (PubMedID: 19287398)

  • Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V.

    Nakagawa Y et al (1997) Biosci Biotechnol Biochem 61(8) : 1415-7.
    Read more (PubMedID: 9301127)

  • (-)-Indolactam V-induced mitogenesis in human fetal/neonatal and adult T cells: lower response of neonatal cells and possible regulatory role of monocytes in protein kinase C-mediated pathways.

    Papadogiannakis N (1995) Cell Immunol 162(2) : 288-94.
    Read more (PubMedID: 7743557)

  • (-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells.

    Heikkilä J et al (1989) Biochem Biophys Res Commun 162(3) : 1207-13.
    Read more (PubMedID: 2764930)

4 Item(s)

Grouped product items
Order: HB0002
Pack PriceQty
1mg
$265
Synthetic PKC activator
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