Product overview
| Name | (-)-Indolactam V |
| Description | Synthetic PKC activator |
| Purity | >99% |
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Biological Data
| Biological description | Synthetic protein kinase C (PKC) inhibitor. Also induces embryonic stem cell differentiation. Displays tumor promoting properties with mitogenic and comitogenic activating effects. |
Solubility & Handling
| Storage instructions | -20°C (desiccate) |
| Solubility overview | Soluble in DMSO (10mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one |
| Molecular Weight | 301.38 |
| Chemical structure | ![(-)-Indolactam V [90365-57-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0002.png "(-)-Indolactam V [90365-57-4]") |
| Molecular Formula | C17H23N3O2 |
| CAS Number | 90365-57-4 |
| SMILES | CC(C)[C@@H]1N(C)c2cccc3[nH]cc(C[C@@H](CO)NC1=O)c23 |
References for (-)-Indolactam V
References are publications that support the biological activity of the product
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A small molecule that directs differentiation of human ESCs into the pancreatic lineage.
Chen S et al (2009) Nat Chem Biol 5(4) : 258-65. -
Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V.
Nakagawa Y et al (1997) Biosci Biotechnol Biochem 61(8) : 1415-7. -
(-)-Indolactam V-induced mitogenesis in human fetal/neonatal and adult T cells: lower response of neonatal cells and possible regulatory role of monocytes in protein kinase C-mediated pathways.
Papadogiannakis N (1995) Cell Immunol 162(2) : 288-94. -
(-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells.
Heikkilä J et al (1989) Biochem Biophys Res Commun 162(3) : 1207-13.
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