Product overview

Name (-)-Indolactam V
Purity >99%
Description Synthetic PKC activator
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Biological Data

Biological description Synthetic protein kinase C (PKC) inhibitor. Also induces embryonic stem cell differentiation. Displays tumor promoting properties with mitogenic and comitogenic activating effects.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >99%
Chemical name (2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one
Molecular Weight 301.38
Chemical structure (-)-Indolactam V  [90365-57-4] Chemical Structure
Molecular Formula C17H23N3O2
CAS Number 90365-57-4
SMILES CC(C)[C@@H]1N(C)c2cccc3[nH]cc(C[C@@H](CO)NC1=O)c23

References for (-)-Indolactam V

References are publications that support the biological activity of the product
  • A small molecule that directs differentiation of human ESCs into the pancreatic lineage.

    Chen S et al (2009) Nat Chem Biol 5(4) : 258-65.
  • Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V.

    Nakagawa Y et al (1997) Biosci Biotechnol Biochem 61(8) : 1415-7.
  • (-)-Indolactam V-induced mitogenesis in human fetal/neonatal and adult T cells: lower response of neonatal cells and possible regulatory role of monocytes in protein kinase C-mediated pathways.

    Papadogiannakis N (1995) Cell Immunol 162(2) : 288-94.
  • (-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells.

    Heikkilä J et al (1989) Biochem Biophys Res Commun 162(3) : 1207-13.

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