Product overview

Name IDRA 21
Description AMPA receptor positive allosteric modulator
Purity >98%
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Biological Data

Biological description AMPA receptor positive allosteric modulator. Enhances long term potentiation and inhibits AMPA receptor desensitization. Increases excitatory synaptic strength. Displays positive effects on cognition in several animal models. Blood brain barrier permeable.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Chemical name 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide
Molecular Weight 232.68
Chemical structure IDRA 21  [22503-72-6] Chemical Structure
Molecular Formula C8H9ClN2O2S
CAS Number 22503-72-6
PubChem identifier 3688
MDL number MFCD00270874

References for IDRA 21

References are publications that support the biological activity of the product
  • The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques.

    Malkova L et al (2011) Neuropharmacology 60(7-8) : 1262-8.
  • 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide: a partial modulator of AMPA receptor desensitization devoid of neurotoxicity.

    Impagnatiello F et al (1997) Proc Natl Acad Sci U S A 94(13) : 7053-8.
  • 7-Chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization.

    Zivkovic I et al (1995) J Pharmacol Exp Ther 272(1) : 300-9.