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Biological Data
| Biological description | AMPA receptor positive allosteric modulator. Enhances long term potentiation and inhibits AMPA receptor desensitization. Increases excitatory synaptic strength. Displays positive effects on cognition in several animal models. Blood brain barrier permeable. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide |
| Chemical structure | ![IDRA 21 [22503-72-6] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "IDRA 21 [22503-72-6]") |
| Molecular Formula | C8H9ClN2O2S |
| SMILES | CC1NC2=C(C=C(Cl)C=C2)S(=O)(=O)N1 |
| InChiKey | VZRNTCHTJRLTMU-UHFFFAOYSA-N |
References for IDRA 21
References are publications that support the biological activity of the product
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The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques.
Malkova L et al (2011) Neuropharmacology 60(7-8) : 1262-8. -
7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide: a partial modulator of AMPA receptor desensitization devoid of neurotoxicity.
Impagnatiello F et al (1997) Proc Natl Acad Sci U S A 94(13) : 7053-8. -
7-Chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization.
Zivkovic I et al (1995) J Pharmacol Exp Ther 272(1) : 300-9.
AMPA receptor positive allosteric modulator
![IDRA 21 [22503-72-6] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0334.png "IDRA 21 [22503-72-6]")
Understanding purity and quality - a guide for life scientists
