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Indo-1 AM

(HB0790)
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Product overview

Name Indo-1 AM
Alternative names Indo-1/AM; Indo-1 acetoxymethylester
Biological description

Cell permeable calcium sensitive flouresecent dye. Binds to Ca2+ (Kd = 0.25 µM). Ratiometric and excited by UV light. Hydrolysed into Indo-1 by cytoplasmic esterases. May be used for monitoring Ca<2+> levels. Inhibits renal proximal tubule cell volume regulation. For optimal cell loading, F-127 is available either as a 10% solution in water (HB16503) and 20% solution in DMSO (HB9631).

Purity >95%
Description Calcium sensitive fluorescent dye
Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4)
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Solubility & Handling

Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name 1-[2-Amino-5-(6-carboxyindol-2-yl)phenoxy]-2-(2\'-amino-5\'-methylphenoxy)ethane-N,N,N\',N\'-tetraacetic acid, pentaacetoxymethylester
Molecular Weight 1009.9
Chemical structure Indo-1 AM [112926-02-0] Chemical Structure
Molecular Formula C47H51N3O22
CAS Number 112926-02-0
SMILES CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)c1ccc(C)cc1OCCOc2cc(ccc2N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)c3[nH]c4cc(ccc4c3)C(=O)OCOC(C)=O

References for Indo-1 AM

References are publications that support the biological activity of the product

  • The source of epifluorescence in isolated perfused heart loaded with fura 2-AM or indo 1-AM.

    Shinozaki T et al (1993) Heart Vessels 8(2) : 79-84.
    Read more (PubMedID: 8314741)

  • The fluorescent calcium indicator indo-1/AM inhibits renal proximal tubule cell volume regulation.

    Kanli H et al (1992) Ann Clin Lab Sci 22(4) : 236-44.
    Read more (PubMedID: 1503391)

  • Calcium mobilization in human platelets using indo-1 and flow cytometry.

    Jennings LK et al (1989) Blood 74(8) : 2674-80.
    Read more (PubMedID: 2510834)

  • A new generation of Ca2+ indicators with greatly improved fluorescence properties.

    Grynkiewicz G et al (1985) J Biol Chem 260(6) : 3440-50.
    Read more (PubMedID: 3838314)

4 Item(s)

Grouped product items
Order: HB0790
Pack PriceQty
1mg
$253
Calcium sensitive fluorescent dye
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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