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IEM-1460

(HB0338)
Publications (4)
Technical documents: SDS CoA Datasheet
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Product overview

Name IEM-1460
Purity >98%
Description Competitive, selective, GluA2 (GluR2)-lacking AMPA receptor blocker
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews Publications (4) References (4) Frequently bought together
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Biological Data

Biological description

Competitive, selective, voltage-dependent open-channel Ca2+ permeable GluA2 (GluR2)-lacking AMPA receptor blocker (IC50 values are 2.6 and 1102 µM at GluA2-lacking and GluA2-containing AMPARs respectively).


IEM-1460 can be utilized as an indicator of the distribution of AMPA receptor subtypes among populations of brain cells.

IEM-1460 can also be used to selectively target GABAergic interneurons, as several subpopulations of these neurons express a significant proportion of GluA2-lacking Ca2+-permeable AMPARs.


Blocks synaptic excitation of fast-spiking interneurons and blocks NMDAR-mediated currents.

Also shows anticonvulsant properties.

Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (100mM) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name N,N,N-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminium bromide hydrobromide
Molecular Weight 454.33
Chemical structure IEM-1460 [121034-89-7] Chemical Structure
Molecular Formula C19H37BrN2.HBr
CAS Number 121034-89-7
PubChem identifier 6604954
SMILES [Br-].Br.C[N+](C)(C)CCCCCNCC13CC2CC(CC(C1)C2)C3
InChiKey CQTDZUSQSTUZDA-UHFFFAOYSA-M

References for IEM-1460

References are publications that support the biological activity of the product

  • Selective inhibition of striatal fast-spiking interneurons causes dyskinesias.

    Gittis et al (2011) J Neurosci 31(44) : 15727-31
    Read more (PubMedID: 22049415)

  • Two mechanisms of action of the adamantane derivative IEM-1460 at human AMPA-type glutamate receptors.

    Schlesinger et al (2005) Br J Pharmacol 145(5) : 656-63
    Read more (PubMedID: 15834439)

  • The open channel blocking drug, IEM-1460, reveals functionally distinct alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors in rat brain neurons.

    Samoilova et al (1999) Neuroscience 94(1) : 261-8
    Read more (PubMedID: 10613516)

  • Characterization of AMPA receptor populations in rat brain cells by the use of subunit-specific open channel blocking drug, IEM-1460.

    Buldakova et al (1999) Brain Res 846(1) : 52-8
    Read more (PubMedID: 10536213)

4 Item(s)

Publications
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These publications cite the use of IEM-1460 purchased from Hello Bio:

  • PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus

    Park P et al (2021) Nat Commun 12(1) : 413
    PubMedID: 33462202

  • The Origin of Physiological Local mGluR1 Supralinear Ca<sup>2+</sup> Signals in Cerebellar Purkinje Neurons

    Ait Ouares K et al (2020) J Neurosci 40(9) : 1795-1809
    PubMedID: 31969470

  • On the Role of Calcium-Permeable AMPARs in Long-Term Potentiation and Synaptic Tagging in the Rodent Hippocampus.

    Park et al (2019) Front Synaptic Neurosci. 14; : 11:4
    PubMedID: 30923499

  • Characterization of calcium signals generated by activation of the two excitatory synaptic inputs in Purkinje neurons

    Ouares et al (2019) University of Paris : Thesis

4 Item(s)

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Grouped product items
Order: HB0338
Pack PriceQty
10mg
$91
50mg
$385
Competitive, selective, GluA2 (GluR2)-lacking AMPA receptor blocker
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