My Cart
My account
Menu
Main Menu

Imatinib mesylate

(HB1943)
Be the first to add a publication
Technical documents: SDS CoA Datasheet
Be the first to review this product
Add to Wish List

Product overview

Name Imatinib mesylate
Purity >98%
Description Tyrosine kinase inhibitor that targets BCR‑ABL, c‑KIT, and PDGFR kinases
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
Write Your Own Review
You're reviewing:Imatinib mesylate
Rate this item:

Biological Data

Biological description

Tyrosine kinase inhibitor that targets BCR‑ABL, c‑KIT, and PDGFR kinases. It binds close to the ATP binding site to inhibit enzyme activity semi-competitively, leading to subsequent inhibition of downstream signaling pathways.

Shows anticancer actions and used in chronic myeloid leukemia research.

Shows antiviral actions against SARS-CoV and MERS-Cov in vitro. Recently investigated as part of COVID-19 compound repurposing.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in water (100mM) and DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >98%
Chemical name 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate
Molecular Weight 589.71
Chemical structure Imatinib mesylate [220127-57-1] Chemical Structure
Molecular Formula C29H31N7O.CH4O3S
CAS Number 220127-57-1
PubChem identifier 123596
SMILES CS(O)(=O)=O.CN1CCN(CC1)CC2=CC=C(C(NC3=CC=C(C(NC4=NC=CC(C5=CN=CC=C5)=N4)=C3)C)=O)C=C2
InChi InChI=1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)
InChiKey YLMAHDNUQAMNNX-UHFFFAOYSA-N

References for Imatinib mesylate

References are publications that support the biological activity of the product

  • Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection

    Dyall J et al (2014) Antimicrob Agents Chemother 58(8) : 4885-93
    Read more (PubMedID: 24841273)

  • Imatinib in chronic myeloid leukemia: an overview

    Sacha T (2014) Mediterr J Hematol Infect Dis 6(1) : e2014007
    Read more (PubMedID: 24455116)

  • Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative

    Buchdunger E et al (1996) Cancer Res 56(1) : 100-4
    Read more (PubMedID: 8548747)

3 Item(s)

Related Products
Grouped product items
Order: HB1943
Pack PriceQty
100mg
$86
Tyrosine kinase inhibitor that targets BCR‑ABL, c‑KIT, and PDGFR kinases
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com

New Products in this Area

Pexidartinib (PLX3397)
HB8991

Potent CSF-1R inhibitor. Widely used microglia-depletion agent.

Related Products

SL327
Code:
HB1350
Pack:
1mg, 10mg, 50mg
Price:
$76, $163, $690
(Free trial)
Selective MEK1 and MEK2 inhibitor
PD 98059
Code:
HB2244
Pack:
1mg, 10mg, 50mg
Price:
$47, $100, $448
(Free trial)
Selective MEK1/MAP2K inhibitor. Enhances ESC self-renewal.
U0126
Code:
HB2246
Pack:
1mg, 5mg, 25mg
Price:
$63, $164, $679
(Free trial)
Potent, selective MEK-1/MEK-2 inhibitor