Indinavir Sulfate

(HB7480)

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Product overview

Name Indinavir Sulfate
Purity >98%
Description Antiretroviral protease inhibitor
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Biological Data

Biological description

Orally activ antiretroviral protease inhibitor which inhibits HIV-1 protease and suppresses HIV replication. It also induces glutathione export from astrocytes.

Recently investigated as part of COVID-19 compound repurposing.

Solubility & Handling

Solubility overview Soluble in water (15 mg/ml)
Storage instructions RT
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide sulphate salt
Molecular Weight 711.87
Chemical structure Indinavir Sulfate [157810-81-6] Chemical Structure
Molecular Formula C36H47N5O4.H2SO4
CAS Number 157810-81-6
PubChem identifier 5462355
SMILES CC(C)(C)NC(=O)[C@@H]1CN(CCN1C[C@H](C[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H]3[C@@H](CC4=CC=CC=C34)O)O)CC5=CN=CC=C5.OS(=O)(=O)O
InChi InChI=1S/C36H47N5O4.H2O4S/c1-36(2,3)39-35(45)31-24-40(22-26-12-9-15-37-21-26)16-17-41(31)23-29(42)19-28(18-25-10-5-4-6-11-25)34(44)38-33-30-14-8-7-13-27(30)20-32(33)43;1-5(2,3)4/h4-15,21,28-29,31-33,42-43H,16-20,22-24H2,1-3H3,(H,38,44)(H,39,45);(H2,1,2,3,
InChiKey NUBQKPWHXMGDLP-HZUPJJOCSA-N
Appearance White solid

References for Indinavir Sulfate

References are publications that support the biological activity of the product
  • HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus

    Yamamoto et al (2004) Biochem Biophys Res Commun . 18(3) : 719-25
  • Indinavir acutely inhibits insulin-stimulated glucose disposal in humans: a randomized, placebo-controlled study

    Grunfeld et al (2002) Clinical Trial 16(5) : F1-8
  • Disposition of indinavir, a potent HIV-1 protease inhibitor, after an oral dose in humans

    Balani et al (1996) Clinical Trial 24(12) : 1389-94

3 Item(s)