Group I (mGlu5, mGlu1)
Group I metabotropic glutamate receptors (mGlu1, mGlu5) are coupled with phospholipase C (PLC) via Gq proteins; activation causes increased levels of IP3 and diacylglycerol, with intracellullar Ca2+ release and protein kinase C (PKC) activation. Group I receptors are predominantly located post synaptically. Researchers can save 50% on group I metabotropic glutamate receptor agonists, antagonists, positive allosteric modulators (PAMs) and negative allosteric modulators (NAMs) from Hello Bio - they are up to half the price of other suppliers.
CAT335 (HB8146)
Description:K2P2.1 (TREK-1) modulator. Selectively and irreversibly activates TREK-1CG* but not wild-type K2P2.1 (TREK-1)
Purity:>98%
CCG 1423 (HB3389)
Description:Rho/SRF pathway inhibitor. Induces intermediate mesoderm differentiation from ESCs.
Purity:>99%
Ceftriaxone disodium salt (HB0176)
Description:β-lactam antibiotic. Increases EAAT2 activity.
Purity:>98%
Celastrol (HB4605)
Description:Anti-oxidant, anti-inflammatory compound with many actions. Topoisomerase II inhibitor.
Purity:>98%
Cesium Gluconate (Cs-Gluc) (HB4822)
Description:Potassium channel blocker. Component in cesium gluconate-based internal solutions used for patch clamp electrophysiology.