Cesium Gluconate (Cs-Gluc)

Technical documents: SDS CoA Datasheet

Product overview

Name Cesium Gluconate (Cs-Gluc)
Alternative names CeGlu, Cs-Gluc, Cs-Gluconate, CsGluconate
Customer comments

We prepared a variety of Cesium Gluconate-based intracellular solutions to record excitatory synaptic currents from brain slices using whole-cell patch clamp. All solutions prepared using the Hello Bio Cesium Gluconate performed exactly as expected, saving us the time and trouble of synthesising the salt “in-house".

Verified customer, the University of Dundee

Description Potassium channel blocker. Component in cesium gluconate-based internal solutions used for patch clamp electrophysiology.
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Cesium Gluconate - scientist approved | Hello Bio
Cesium Gluconate (Cs-Gluc) product vial image | Hello Bio

Biological Data

Biological description

Cesium gluconate is used as a component in cesium gluconate-based internal (intracellular) solutions for patch clamp electrophysiology.

Cesium blocks potassium (K+) channels and K+ currents to help provide a good space clamp.

Cesium-gluconate based internal solutions are commonly used for voltage-clamp applications and are useful when studying EPSCs (excitatory postsynaptic currents) / IPSCs (inhibitory postsynaptic currents).

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in water (200 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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More Info

Chemical Data

Chemical name D-Gluconic acid cesium salt
Molecular Weight 328.05
Chemical structure Cesium gluconate Chemical Structure
Molecular Formula C6H11CsO7
SMILES O[C@H]([C@@H](O)C(=O)O[Cs])[C@H](O)[C@H](O)CO
Source Synthetic
InChi InChI=1S/C6H12O7.Cs/c7-1-2(8)3(9)4(10)5(11)6(12)13;/h2-5,7-11H,1H2,(H,12,13);/q;+1/p-1/t2-,3-,4+,5-;/m1./s1
Appearance White solid

References for Cesium Gluconate (Cs-Gluc)

References are publications that support the biological activity of the product
  • An ion's view of the potassium channel. The structure of the permeation pathway as sensed by a variety of blocking ions.

    French and Shoukimas (1985) J Gen Physiol 85(5) : 669-98
  • Analysis of the effects of cesium ions on potassium channel currents in biological membranes.

    Clay and Shlesinger (1984) J Theor Biol 107(2) : 189-201
  • Voltage clamp studies on the effect of internal cesium ion on sodium and potassium currents in the squid giant axon.

    Adelman and Senft (1966) J Gen Physiol 50(2) : 279-93

3 Item(s)

These publications cite the use of Cesium Gluconate (Cs-Gluc) purchased from Hello Bio:
  • Astrocytic β-catenin signaling via TCF7L2 regulates synapse development and social behavior.

    Szewczyk LM et al (2023) Molecular psychiatry
    PubMedID: 37798419
  • Tracking the dynamics of single fused synaptic vesicle proteins from a single ribbon active zone in zebrafish retinal bipolar cells

    Shrestha AP et al (2022) STAR Protoc 3(1) : 101107
    PubMedID: 35098163
  • A High-Throughput Screening Assay to Identify Drugs that Can Treat Long QT Syndrome Caused by Trafficking-Deficient KV11.1 (hERG) Variants

    Egly CL et al (2022) Mol Pharmacol 101(4) : 236-245
    PubMedID: 35125346
  • Inhibition of the Akt/PKB Kinase Increases Nav1.6-Mediated Currents and Neuronal Excitability in CA1 Hippocampal Pyramidal Neurons

    Marosi M et al (2022) Int J Mol Sci 23(3)
    PubMedID: 35163623
  • The gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons

    Jehasse K et al (2021) Neuropharmacology 197 : 108722
    PubMedID: 34273387

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