Product overview
| Name | Cesium Gluconate (Cs-Gluc) |
| Description | Potassium channel blocker. Component in cesium gluconate-based internal solutions used for patch clamp electrophysiology. |
| Alternative names | CeGlu, Cs-Gluc, Cs-Gluconate, CsGluconate |
| Customer comments | We prepared a variety of Cesium Gluconate-based intracellular solutions to record excitatory synaptic currents from brain slices using whole-cell patch clamp. All solutions prepared using the Hello Bio Cesium Gluconate performed exactly as expected, saving us the time and trouble of synthesising the salt “in-house". Verified customer, the University of Dundee |
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Biological Data
| Biological description | Cesium gluconate is used as a component in cesium gluconate-based internal (intracellular) solutions for patch clamp electrophysiology. Cesium blocks potassium (K+) channels and K+ currents to help provide a good space clamp. Cesium-gluconate based internal solutions are commonly used for voltage-clamp applications and are useful when studying EPSCs (excitatory postsynaptic currents) / IPSCs (inhibitory postsynaptic currents). |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in water (200 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | D-Gluconic acid cesium salt |
| Molecular Weight | 328.05 |
| Chemical structure |  |
| Molecular Formula | C6H11CsO7 |
| SMILES | O[C@H]([C@@H](O)C(=O)O[Cs])[C@H](O)[C@H](O)CO |
| Source | Synthetic |
| InChi | InChI=1S/C6H12O7.Cs/c7-1-2(8)3(9)4(10)5(11)6(12)13;/h2-5,7-11H,1H2,(H,12,13);/q;+1/p-1/t2-,3-,4+,5-;/m1./s1 |
| InChiKey | IDGWYOYDRLQSAS-JJKGCWMISA-M |
| Appearance | White solid |
References for Cesium Gluconate (Cs-Gluc)
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An ion's view of the potassium channel. The structure of the permeation pathway as sensed by a variety of blocking ions.
French and Shoukimas (1985) J Gen Physiol 85(5) : 669-98 -
Analysis of the effects of cesium ions on potassium channel currents in biological membranes.
Clay and Shlesinger (1984) J Theor Biol 107(2) : 189-201 -
Voltage clamp studies on the effect of internal cesium ion on sodium and potassium currents in the squid giant axon.
Adelman and Senft (1966) J Gen Physiol 50(2) : 279-93
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Tracking the dynamics of single fused synaptic vesicle proteins from a single ribbon active zone in zebrafish retinal bipolar cells
Shrestha AP et al (2022) STAR Protoc 3(1) : 101107PubMedID: 35098163 -
The gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons
Jehasse K et al (2021) Neuropharmacology 197 : 108722PubMedID: 34273387 -
GABAergic neuronal IL-4R mediates T cell effect on memory
Herz J et al (2021) Neuron 109(22) : 3609-3618.e9PubMedID: 34793707 -
Macromolecular and electrical coupling between inner hair cells in the rodent cochlea
Jean P et al (2020) Nat Commun 11(1) : 3208PubMedID: 32587250 -
An unconventional conductance is required for pacemaking of nigral dopamine neurons
Seutin et al (2020) bioRxiv https://doi.org/10.1101/2020.12.16.423073 : doi
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