Cesium Gluconate (Cs-Gluc)

(HB4822)
Technical documents: SDS CoA Datasheet

Product overview

Name Cesium Gluconate (Cs-Gluc)
Description Potassium channel blocker. Component in cesium gluconate-based internal solutions used for patch clamp electrophysiology.
Alternative names CeGlu, Cs-Gluc, Cs-Gluconate, CsGluconate
Customer comments

We prepared a variety of Cesium Gluconate-based intracellular solutions to record excitatory synaptic currents from brain slices using whole-cell patch clamp. All solutions prepared using the Hello Bio Cesium Gluconate performed exactly as expected, saving us the time and trouble of synthesising the salt “in-house".

Verified customer, the University of Dundee

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Images

Cesium Gluconate - scientist approved | Hello Bio
Cesium Gluconate (Cs-Gluc) product vial image | Hello Bio

Biological Data

Biological description

Cesium gluconate is used as a component in cesium gluconate-based internal (intracellular) solutions for patch clamp electrophysiology.


Cesium blocks potassium (K+) channels and K+ currents to help provide a good space clamp.


Cesium-gluconate based internal solutions are commonly used for voltage-clamp applications and are useful when studying EPSCs (excitatory postsynaptic currents) / IPSCs (inhibitory postsynaptic currents).


Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in water (200 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name D-Gluconic acid cesium salt
Molecular Weight 328.05
Chemical structure Cesium gluconate Chemical Structure
Molecular Formula C6H11CsO7
SMILES O[C@H]([C@@H](O)C(=O)O[Cs])[C@H](O)[C@H](O)CO
Source Synthetic
InChi InChI=1S/C6H12O7.Cs/c7-1-2(8)3(9)4(10)5(11)6(12)13;/h2-5,7-11H,1H2,(H,12,13);/q;+1/p-1/t2-,3-,4+,5-;/m1./s1
InChiKey IDGWYOYDRLQSAS-JJKGCWMISA-M
Appearance White solid

References for Cesium Gluconate (Cs-Gluc)

References are publications that support the biological activity of the product
  • An ion's view of the potassium channel. The structure of the permeation pathway as sensed by a variety of blocking ions.

    French and Shoukimas (1985) J Gen Physiol 85(5) : 669-98
  • Analysis of the effects of cesium ions on potassium channel currents in biological membranes.

    Clay and Shlesinger (1984) J Theor Biol 107(2) : 189-201
  • Voltage clamp studies on the effect of internal cesium ion on sodium and potassium currents in the squid giant axon.

    Adelman and Senft (1966) J Gen Physiol 50(2) : 279-93
Publications
These publications cite the use of Cesium Gluconate (Cs-Gluc) purchased from Hello Bio:
  • Tracking the dynamics of single fused synaptic vesicle proteins from a single ribbon active zone in zebrafish retinal bipolar cells

    Shrestha AP et al (2022) STAR Protoc 3(1) : 101107
    PubMedID: 35098163
  • The gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons

    Jehasse K et al (2021) Neuropharmacology 197 : 108722
    PubMedID: 34273387
  • GABAergic neuronal IL-4R mediates T cell effect on memory

    Herz J et al (2021) Neuron 109(22) : 3609-3618.e9
    PubMedID: 34793707
  • Macromolecular and electrical coupling between inner hair cells in the rodent cochlea

    Jean P et al (2020) Nat Commun 11(1) : 3208
    PubMedID: 32587250
  • An unconventional conductance is required for pacemaking of nigral dopamine neurons

    Seutin et al (2020) bioRxiv https://doi.org/10.1101/2020.12.16.423073 : doi

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