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CFM-2

(HB0179)
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Product overview

Name CFM-2
Purity >98%
Description Selective, non-competitive AMPA receptor antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (3)
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Biological Data

Biological description Selective and non-competitive AMPA receptor antagonist. Inhibits ERK1/2 pathway and acts as an antiproliferative agent. Also shows anticonvulsant actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >98%
Chemical name 1-(4'-Aminophenyl)-3,5-dihydro-7,8-dimethoxy-4H-2,3-benzodiazepin-4-one
Molecular Weight 311.34
Chemical structure CFM-2 [178616-26-7] Chemical Structure
Molecular Formula C17H17N3O3
CAS Number 178616-26-7
PubChem identifier 4377504
SMILES COC1=CC2=C(C=C1OC)C(=NNC(=O)C2)C1=CC=C(N)C=C1
InChiKey MJKADKZSYQWGLL-UHFFFAOYSA-N

References for CFM-2

References are publications that support the biological activity of the product

  • AMPA antagonists inhibit the extracellular signal regulated kinase pathway and suppress lung cancer growth.

    Stepulak A et al (2007) Cancer Biol Ther 6(12) : 1908-15.
    Read more (PubMedID: 18059166)

  • Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats.

    De Sarro G et al (1999) Eur J Pharmacol 368(2-3) : 149-59.
    Read more (PubMedID: 10193651)

  • 1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists.

    Chimirri A et al (1997) J Med Chem 40(8) : 1258-69.
    Read more (PubMedID: 9111300)

3 Item(s)

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Order: HB0179
Pack PriceQty
50mg
$620
Selective, non-competitive AMPA receptor antagonist
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