DREADD
Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).
Palitantin (HB4012)
Description:Metabolite of Penicillium with antiprotozoal and antifungal activity
Purity:>95%
-
Pam2CSK4 (HB3086)
Description:TLR2/6 activator. Induces potent NF-κB activation and cytokine production.
-
Pam3CSK4 (HB3428)
Description:TLR1/TLR2 agonist and potent NF-κB activator. Induces cytokine production.
-
Paroxetine hydrochloride (HB0478)
Description:Potent, selective serotonin reuptake inhibitor. Selective GRK2 inhibitor.
Purity:>99%
-
Anti-Parvalbumin antibody ValidAbâ„¢ (HB6457)
Description:Antibody to Parvalbumin - calcium binding protein used as a marker for an inhibitory interneuron subtype. Part of the ValidAbâ„¢ range of highly validated, data-rich antibodies.
Host: MouseClonality: MonoclonalReactivity Tested: Mouse, Rat -
Paxilline (HB1056)
Description:Potent, reversible, selective KCa channel inhibitor. Also SERCA inhibitor.
Purity:>98%
-
