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Paroxetine hydrochloride

(HB0478)
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Product overview

Name Paroxetine hydrochloride
Alternative names Paxil
Purity >99%
Description Potent, selective serotonin reuptake inhibitor. Selective GRK2 inhibitor.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Paroxetine hydrochloride product vial image | Hello Bio
Paroxetine hydrochloride product vial image | Hello Bio

Paroxetine hydrochloride product vial image | Hello Bio

Paroxetine hydrochloride product vial image | Hello Bio

Biological Data

Biological description Potent and selective serotonin (5-HT) reuptake inhibitor (Ki = 0.05 nM). Binds to the serotonin transporter (SERT). Also inhibits Norepinephrine transporter (NET) and increases NET and SERT expression. Additionally acts as a selective G-protein-receptor-kinase2 (GRK2) inhibitor, showing >50-fold selectivity over other GRKs. Shows antidepressant and anxiolytic actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >99%
Chemical name (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine;hydrochloride
Molecular Weight 365.82
Chemical structure Paroxetine HCl [78246-49-8] Chemical Structure
Molecular Formula C19H21ClFNO3
CAS Number 78246-49-8
PubChem identifier 62878
SMILES C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.Cl
InChi InChI=1S/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;/h1-6,9,14,17,21H,7-8,10-12H2;1H/t14-,17-;/m0./s1
InChiKey GELRVIPPMNMYGS-RVXRQPKJSA-N
MDL number MFCD03658863

References for Paroxetine hydrochloride

References are publications that support the biological activity of the product

  • Antidepressive effect of paroxetine in a rat model: upregulating expression of serotonin and norepinephrine transporter.

    Qiu HM et al (2013) Neuroreport 24(10) : 520-5.
    Read more (PubMedID: 23636256)

  • Neuropharmacology of paroxetine.

    Nemeroff CB et al (2003) Psychopharmacol Bull 37 Suppl 1 : 8-18.
    Read more (PubMedID: 14566196)

  • Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.

    Owens MJ et al (1997) J Pharmacol Exp Ther 283(3) : 1305-22.
    Read more (PubMedID: 9400006)

3 Item(s)

Grouped product items
Order: HB0478
Pack PriceQty
10mg
$102
50mg
$406
Potent, selective serotonin reuptake inhibitor. Selective GRK2 inhibitor.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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