Paroxetine hydrochloride
(HB0478)
Product overview
| Name | Paroxetine hydrochloride |
| Description | Potent, selective serotonin reuptake inhibitor. Selective GRK2 inhibitor. |
| Alternative names | Paxil |
| Purity | >99% |
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Biological Data
| Biological description | Potent and selective serotonin (5-HT) reuptake inhibitor (Ki = 0.05 nM). Binds to the serotonin transporter (SERT). Also inhibits Norepinephrine transporter (NET) and increases NET and SERT expression. Additionally acts as a selective G-protein-receptor-kinase2 (GRK2) inhibitor, showing >50-fold selectivity over other GRKs. Shows antidepressant and anxiolytic actions. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in DMSO (100 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine;hydrochloride |
| Molecular Weight | 365.82 |
| Chemical structure | ![Paroxetine HCl [78246-49-8] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0478.png "Paroxetine HCl [78246-49-8]") |
| Molecular Formula | C19H21ClFNO3 |
| CAS Number | 78246-49-8 |
| PubChem identifier | 62878 |
| SMILES | C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.Cl |
| InChi | InChI=1S/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;/h1-6,9,14,17,21H,7-8,10-12H2;1H/t14-,17-;/m0./s1 |
| InChiKey | GELRVIPPMNMYGS-RVXRQPKJSA-N |
| MDL number | MFCD03658863 |
References for Paroxetine hydrochloride
References are publications that support the biological activity of the product
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Antidepressive effect of paroxetine in a rat model: upregulating expression of serotonin and norepinephrine transporter.
Qiu HM et al (2013) Neuroreport 24(10) : 520-5. -
Neuropharmacology of paroxetine.
Nemeroff CB et al (2003) Psychopharmacol Bull 37 Suppl 1 : 8-18. -
Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.
Owens MJ et al (1997) J Pharmacol Exp Ther 283(3) : 1305-22.
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