Product overview

Name Paroxetine hydrochloride
Description Potent, selective serotonin reuptake inhibitor. Selective GRK2 inhibitor.
Alternative names Paxil
Purity >99%
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Biological Data

Biological description Potent and selective serotonin (5-HT) reuptake inhibitor (Ki = 0.05 nM). Binds to the serotonin transporter (SERT). Also inhibits Norepinephrine transporter (NET) and increases NET and SERT expression. Additionally acts as a selective G-protein-receptor-kinase2 (GRK2) inhibitor, showing >50-fold selectivity over other GRKs. Shows antidepressant and anxiolytic actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Chemical name (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine;hydrochloride
Molecular Weight 365.82
Chemical structure Paroxetine HCl  [78246-49-8] Chemical Structure
Molecular Formula C19H21ClFNO3
CAS Number 78246-49-8
PubChem identifier 62878
InChi InChI=1S/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;/h1-6,9,14,17,21H,7-8,10-12H2;1H/t14-,17-;/m0./s1
MDL number MFCD03658863

References for Paroxetine hydrochloride

References are publications that support the biological activity of the product
  • Antidepressive effect of paroxetine in a rat model: upregulating expression of serotonin and norepinephrine transporter.

    Qiu HM et al (2013) Neuroreport 24(10) : 520-5.
  • Neuropharmacology of paroxetine.

    Nemeroff CB et al (2003) Psychopharmacol Bull 37 Suppl 1 : 8-18.
  • Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.

    Owens MJ et al (1997) J Pharmacol Exp Ther 283(3) : 1305-22.