Product overview

Name Pam3CSK4

TLR1/TLR2 agonist and potent NF-κB activator. Induces cytokine production.

Biological description

Synthetic lipopeptide that mimics bacterial lipoprotein. Acts as an agonist of the Toll-like receptor TLR1/TLR2 complex to potently activate NF-κB. Activates monocytes and macrophages and induces cytokine production (e.g. TNF-α and IL-6 in macrophages). Also upregulates proinflammatory and Th1 cytokine genes and promotes differentiation of naive CD4+ T cells into Th17 cells. Additionally acts as an effective immune adjuvant.

Alternative names Pam3CysSerLys4, Pam3
Purity >95%
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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (1 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



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Chemical Data

Molecular Weight 1510.24
Molecular Formula C81H156N10O13S

Sequence (one letter) CSKKKK
Modifications (Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R/S)-propyl]-N-palmitoyl]-Cys
CAS Number 112208-00-1
PubChem identifier 130704
Appearance White solid

References for Pam3CSK4

References are publications that support the biological activity of the product
  • Detection of the Lipopeptide Pam3CSK4 Using a Hybridized Toll-like Receptor Electrochemical Sensor.

    She Z et al (2017) Analytical chemistry 89 : 4882-4888
  • The synthetic bacterial lipopeptide Pam3CSK4 modulates respiratory syncytial virus infection independent of TLR activation.

    Nguyen DT et al (2010) PLoS pathogens 6 : e1001049
  • Toll-like receptor 2 agonist Pam3CSK4 enhances the induction of antigen-specific tolerance via the sublingual route.

    Lombardi V et al (2008) Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 38 : 1819-29

3 Item(s)