Product overview
Name | Pam3CSK4 |
Description | TLR1/TLR2 agonist and potent NF-κB activator. Induces cytokine production. |
Biological description | Synthetic lipopeptide that mimics bacterial lipoprotein. Acts as an agonist of the Toll-like receptor TLR1/TLR2 complex to potently activate NF-κB. Activates monocytes and macrophages and induces cytokine production (e.g. TNF-α and IL-6 in macrophages). Also upregulates proinflammatory and Th1 cytokine genes and promotes differentiation of naive CD4+ T cells into Th17 cells. Additionally acts as an effective immune adjuvant. |
Alternative names | Pam3CysSerLys4, Pam3 |
Purity | >95% |
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Solubility & Handling
Storage instructions | -20°C |
Solubility overview | Soluble in water (1 mg/ml) |
Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
Molecular Weight | 1510.24 |
Molecular Formula | C81H156N10O13S |
Sequence (one letter) | CSKKKK |
Modifications | (Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R/S)-propyl]-N-palmitoyl]-Cys |
CAS Number | 112208-00-1 |
PubChem identifier | 130704 |
InChiKey | OEDPHAKKZGDBEV-GFPBKZJXSA-N |
Appearance | White solid |
References for Pam3CSK4
References are publications that support the biological activity of the product
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Detection of the Lipopeptide Pam3CSK4 Using a Hybridized Toll-like Receptor Electrochemical Sensor.
She Z et al (2017) Analytical chemistry 89 : 4882-4888 -
The synthetic bacterial lipopeptide Pam3CSK4 modulates respiratory syncytial virus infection independent of TLR activation.
Nguyen DT et al (2010) PLoS pathogens 6 : e1001049 -
Toll-like receptor 2 agonist Pam3CSK4 enhances the induction of antigen-specific tolerance via the sublingual route.
Lombardi V et al (2008) Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 38 : 1819-29