Product overview
| Name | Pam3CSK4 |
| Description | TLR1/TLR2 agonist and potent NF-κB activator. Induces cytokine production. |
| Biological description | Synthetic lipopeptide that mimics bacterial lipoprotein. Acts as an agonist of the Toll-like receptor TLR1/TLR2 complex to potently activate NF-κB. Activates monocytes and macrophages and induces cytokine production (e.g. TNF-α and IL-6 in macrophages). Also upregulates proinflammatory and Th1 cytokine genes and promotes differentiation of naive CD4+ T cells into Th17 cells. Additionally acts as an effective immune adjuvant. |
| Alternative names | Pam3CysSerLys4, Pam3 |
| Purity | >95% |
Write Your Own Review
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in water (1 mg/ml) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Molecular Weight | 1510.24 |
| Molecular Formula | C81H156N10O13S |
| Sequence (one letter) | CSKKKK |
| Modifications | (Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R/S)-propyl]-N-palmitoyl]-Cys |
| CAS Number | 112208-00-1 |
| PubChem identifier | 130704 |
| InChiKey | OEDPHAKKZGDBEV-GFPBKZJXSA-N |
| Appearance | White solid |
References for Pam3CSK4
References are publications that support the biological activity of the product
-
Detection of the Lipopeptide Pam3CSK4 Using a Hybridized Toll-like Receptor Electrochemical Sensor.
She Z et al (2017) Analytical chemistry 89 : 4882-4888 -
The synthetic bacterial lipopeptide Pam3CSK4 modulates respiratory syncytial virus infection independent of TLR activation.
Nguyen DT et al (2010) PLoS pathogens 6 : e1001049 -
Toll-like receptor 2 agonist Pam3CSK4 enhances the induction of antigen-specific tolerance via the sublingual route.
Lombardi V et al (2008) Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 38 : 1819-29
Technical guides
Understanding purity and quality - a guide for life scientistsRelated Products
New Products in this Area
Related Products
- Code:
- HB0502
PKC activator. Widely used for THP-1 cell differentiation and with ionomycin ...