TLR1/TLR2 agonist and potent NF-κB activator. Induces cytokine production.
Synthetic lipopeptide that mimics bacterial lipoprotein. Acts as an agonist of the Toll-like receptor TLR1/TLR2 complex to potently activate NF-κB. Activates monocytes and macrophages and induces cytokine production (e.g. TNF-α and IL-6 in macrophages). Also upregulates proinflammatory and Th1 cytokine genes and promotes differentiation of naive CD4+ T cells into Th17 cells. Additionally acts as an effective immune adjuvant.