Product overview

Name Pam3CSK4
Biological description

Synthetic lipopeptide that mimics bacterial lipoprotein. Acts as an agonist of the Toll-like receptor TLR1/TLR2 complex to potently activate NF-κB. Activates monocytes and macrophages and induces cytokine production (e.g. TNF-α and IL-6 in macrophages). Also upregulates proinflammatory and Th1 cytokine genes and promotes differentiation of naive CD4+ T cells into Th17 cells. Additionally acts as an effective immune adjuvant.

Alternative names Pam3CysSerLys4, Pam3
Purity >95%
Description

TLR1/TLR2 agonist and potent NF-κB activator. Induces cytokine production.

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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (1 mg/ml)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Dilution

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Chemical Data

Purity >95%
Molecular Weight 1510.24
Molecular Formula C81H156N10O13S

Sequence (one letter) CSKKKK
Modifications (Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R/S)-propyl]-N-palmitoyl]-Cys
CAS Number 112208-00-1
PubChem identifier 130704
InChiKey OEDPHAKKZGDBEV-GFPBKZJXSA-N
Appearance White solid

References for Pam3CSK4

References are publications that support the biological activity of the product
  • Detection of the Lipopeptide Pam3CSK4 Using a Hybridized Toll-like Receptor Electrochemical Sensor.

    She Z et al (2017) Analytical chemistry 89 : 4882-4888
  • The synthetic bacterial lipopeptide Pam3CSK4 modulates respiratory syncytial virus infection independent of TLR activation.

    Nguyen DT et al (2010) PLoS pathogens 6 : e1001049
  • Toll-like receptor 2 agonist Pam3CSK4 enhances the induction of antigen-specific tolerance via the sublingual route.

    Lombardi V et al (2008) Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 38 : 1819-29

3 Item(s)