Pam3CSK4

Synthetic lipopeptide that mimics bacterial lipoprotein. Acts as an agonist of the Toll-like receptor TLR1/TLR2 complex to potently activate NF-κB. Activates monocytes and macrophages and induces cytokine production (e.g. TNF-α and IL-6 in macrophages). Also upregulates proinflammatory and T_h1 cytokine genes and promotes differentiation of naive CD4+ T cells into T_h17 cells. Additionally acts as an effective immune adjuvant.

TLR1/TLR2 agonist and potent NF-κB activator. Induces cytokine production.