Synthetic lipopeptide that mimics bacterial lipoprotein. Acts as an agonist of the Toll-like receptor TLR1/TLR2 complex to potently activate NF-κB. Activates monocytes and macrophages and induces cytokine production (e.g. TNF-α and IL-6 in macrophages). Also upregulates proinflammatory and Th1 cytokine genes and promotes differentiation of naive CD4+ T cells into Th17 cells. Additionally acts as an effective immune adjuvant.
Alternative names
Pam3CysSerLys4, Pam3
Purity
>95%
Description
TLR1/TLR2 agonist and potent NF-κB activator. Induces cytokine production.
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Understanding purity and quality - a guide for life scientists
