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Biological Data

Biological description Potent and selective histone deacetylase 8 (HDAC8) inhibitor (IC50 = 10 nM). Shows >200-fold selectivity over other HDAC isoforms (IC50 values are 2.9, 4, 13, >50 and >50 µM for HDAC6, 1, 10, 2 and 3 respectively). Shows apoptotic and anti-cancer actions.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in NaOH(aq) (20mM, 1eq. NaOH) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name N-Hydroxy-1-[(4-methoxyphenyl)methy l]-1H-indole-6-carboxamide
Molecular Weight 296.32
Chemical structure PCI 34051  [950762-95-5] Chemical Structure
Molecular Formula C17H16N2O3
CAS Number 950762-95-5
PubChem identifier 24753719
SMILES O=C(NO)C1=CC=C2C(N(CC3=CC=C(OC)C=C3)C=C2)=C1
InChiKey AJRGHIGYPXNABY-UHFFFAOYSA-N

References for PCI 34051

References are publications that support the biological activity of the product
  • HDAC8-mediated epigenetic reprogramming plays a key role in resistance to anthrax lethal toxin-induced pyroptosis in macrophages.

    Ha SD et al (2014) J Immunol 193(3) : 1333-43.
  • Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain.

    Wang C et al (2013) Am J Nucl Med Mol Imaging 4(1) : 29-38.
  • A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas.

    Balasubramanian S et al (2008) Leukemia 22(5) : 1026-34.