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Biological Data
| Biological description | Potent and selective histone deacetylase 8 (HDAC8) inhibitor (IC50 = 10 nM). Shows >200-fold selectivity over other HDAC isoforms (IC50 values are 2.9, 4, 13, >50 and >50 µM for HDAC6, 1, 10, 2 and 3 respectively). Shows apoptotic and anti-cancer actions. |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in NaOH(aq) (20mM, 1eq. NaOH) or DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | N-Hydroxy-1-[(4-methoxyphenyl)methy l]-1H-indole-6-carboxamide |
| Chemical structure | ![PCI 34051 [950762-95-5] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "PCI 34051 [950762-95-5]") |
| Molecular Formula | C17H16N2O3 |
| PubChem identifier | 24753719 |
| SMILES | O=C(NO)C1=CC=C2C(N(CC3=CC=C(OC)C=C3)C=C2)=C1 |
| InChiKey | AJRGHIGYPXNABY-UHFFFAOYSA-N |
References for PCI 34051
References are publications that support the biological activity of the product
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HDAC8-mediated epigenetic reprogramming plays a key role in resistance to anthrax lethal toxin-induced pyroptosis in macrophages.
Ha SD et al (2014) J Immunol 193(3) : 1333-43. -
Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain.
Wang C et al (2013) Am J Nucl Med Mol Imaging 4(1) : 29-38. -
A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas.
Balasubramanian S et al (2008) Leukemia 22(5) : 1026-34.
Potent, selective HDAC8 inhibitor
![PCI 34051 [950762-95-5] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1393.png "PCI 34051 [950762-95-5]")
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