Product overview

Name Paxilline
Description Potent, reversible, selective KCa channel inhibitor. Also SERCA inhibitor.
Purity >98%
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Biological Data

Biological description Potent, reversible and selective KCa channel inhibitor (Ki = 1.9 nM at α-subunit). Also sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor (IC50 = 5-50 µM). Indole alkaloid mycotoxin from Penicillium paxilli. Displays anticonvulsant properties.

Solubility & Handling

Storage instructions -20°C (desiccate)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name (2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a, 7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-h ydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2 '',3'':5',6']benz[1',2':6,7]indeno[1,2-b]indol-3(4bH)-one
Molecular Weight 435.56
Chemical structure Paxilline  [57186-25-1] Chemical Structure
Molecular Formula C27H33NO4
CAS Number 57186-25-1
PubChem identifier 105008
SMILES [H][C@@]4([C@](C)3[C@]5(C)[C@@](C([C@]6([H])CC5)=CC([C@@H]([C@](O)(C)C)O6)=O)(O)CC4)CC2=C3NC1=CC=CC=C12
InChiKey ACNHBCIZLNNLRS-UBGQALKQSA-N

References for Paxilline

References are publications that support the biological activity of the product
  • Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix.

    Zhou Y et al (2010) J Gen Physiol 135(5) : 481-94.
  • Anticonvulsant effects of the BK-channel antagonist paxilline.

    Sheehan JJ et al (2009) Epilepsia 50(4) : 711-20.
  • The mechanism of inhibition of the sarco/endoplasmic reticulum Ca2+ ATPase by paxilline.

    Bilmen JG et al (2002) Arch Biochem Biophys 406(1) : 55-64.
  • Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel.

    Sanchez M et al (1996) Neuropharmacology 35(7) : 963-8.