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Paxilline

(HB1056)
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Product overview

Name Paxilline
Purity >98%
Description Potent, reversible, selective KCa channel inhibitor. Also SERCA inhibitor.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4) Frequently bought together
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Biological Data

Biological description Potent, reversible and selective KCa channel inhibitor (Ki = 1.9 nM at α-subunit). Also sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor (IC50 = 5-50 µM). Indole alkaloid mycotoxin from Penicillium paxilli. Displays anticonvulsant properties.

Solubility & Handling

Storage instructions -20°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a, 7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-h ydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2 '',3'':5',6']benz[1',2':6,7]indeno[1,2-b]indol-3(4bH)-one
Molecular Weight 435.56
Chemical structure Paxilline [57186-25-1] Chemical Structure
Molecular Formula C27H33NO4
CAS Number 57186-25-1
PubChem identifier 105008
SMILES [H][C@@]4([C@](C)3[C@]5(C)[C@@](C([C@]6([H])CC5)=CC([C@@H]([C@](O)(C)C)O6)=O)(O)CC4)CC2=C3NC1=CC=CC=C12
InChiKey ACNHBCIZLNNLRS-UBGQALKQSA-N

References for Paxilline

References are publications that support the biological activity of the product

  • Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix.

    Zhou Y et al (2010) J Gen Physiol 135(5) : 481-94.
    Read more (PubMedID: 20421373)

  • Anticonvulsant effects of the BK-channel antagonist paxilline.

    Sheehan JJ et al (2009) Epilepsia 50(4) : 711-20.
    Read more (PubMedID: 19054419)

  • The mechanism of inhibition of the sarco/endoplasmic reticulum Ca2+ ATPase by paxilline.

    Bilmen JG et al (2002) Arch Biochem Biophys 406(1) : 55-64.
    Read more (PubMedID: 12234490)

  • Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel.

    Sanchez M et al (1996) Neuropharmacology 35(7) : 963-8.
    Read more (PubMedID: 8938726)

4 Item(s)

Grouped product items
Order: HB1056
Pack PriceQty
5mg
$153
Potent, reversible, selective KCa channel inhibitor. Also SERCA inhibitor.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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