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Biological Data
| Biological description | Potent, reversible and selective KCa channel inhibitor (Ki = 1.9 nM at α-subunit). Also sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor (IC50 = 5-50 µM). Indole alkaloid mycotoxin from Penicillium paxilli. Displays anticonvulsant properties. |
Solubility & Handling
| Storage instructions | -20°C (desiccate) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a, 7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-h ydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2 '',3'':5',6']benz[1',2':6,7]indeno[1,2-b]indol-3(4bH)-one |
| Chemical structure | ![Paxilline [57186-25-1] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Paxilline [57186-25-1]") |
| Molecular Formula | C27H33NO4 |
| PubChem identifier | 105008 |
| SMILES | [H][C@@]4([C@](C)3[C@]5(C)[C@@](C([C@]6([H])CC5)=CC([C@@H]([C@](O)(C)C)O6)=O)(O)CC4)CC2=C3NC1=CC=CC=C12 |
| InChiKey | ACNHBCIZLNNLRS-UBGQALKQSA-N |
References for Paxilline
References are publications that support the biological activity of the product
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Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix.
Zhou Y et al (2010) J Gen Physiol 135(5) : 481-94. -
Anticonvulsant effects of the BK-channel antagonist paxilline.
Sheehan JJ et al (2009) Epilepsia 50(4) : 711-20. -
The mechanism of inhibition of the sarco/endoplasmic reticulum Ca2+ ATPase by paxilline.
Bilmen JG et al (2002) Arch Biochem Biophys 406(1) : 55-64. -
Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel.
Sanchez M et al (1996) Neuropharmacology 35(7) : 963-8.
Potent, reversible, selective KCa channel inhibitor. Also SERCA inhibitor.
![Paxilline [57186-25-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1056.png "Paxilline [57186-25-1]")
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